Cardiovascular DiseasesDexilant (Generic)
Generic drugs, marketed without brand names, contain the exact same active ingredients used in their brand-name counterparts, but cost significantly less. The drugs are required to meet US Food and Drug Administration (FDA) standards for safety, purity and effectiveness.
Dexilant
Heartburn brought on by gastroesophageal reflux disease (GERD) can be treated with dexlansoprazole, and the medication can also be used to mend erosive esophagitis (damage to the esophagus from stomach acid).
Introduction: Dexilant, known generically as dexlansoprazole, is a proton pump inhibitor (PPI) used to treat conditions related to excessive stomach acid production. It is commonly prescribed for gastroesophageal reflux disease (GERD), including erosive esophagitis and non-erosive reflux disease (NERD), as well as for the maintenance of healed erosive esophagitis. Dexilant is a modified-release formulation of lansoprazole, designed to provide prolonged acid suppression and improved symptom relief.
Mechanism of Action: Dexilant works by inhibiting the hydrogen-potassium adenosine triphosphatase (H+/K+ ATPase) enzyme system, also known as the proton pump, located on the secretory surface of gastric parietal cells. By blocking this enzyme, Dexilant reduces the production of gastric acid, thereby decreasing acidity in the stomach. This mechanism helps alleviate symptoms such as heartburn, regurgitation, and stomach discomfort associated with acid-related disorders.
Key Features:
Dual Delayed-Release Technology: Dexilant utilizes a unique dual delayed-release formulation, which allows for two separate releases of the medication. The first release occurs within 1-2 hours after ingestion, and the second release occurs 4-5 hours later. This design provides prolonged acid suppression over a 24-hour period, making it effective for managing both daytime and nighttime symptoms.
Indications:
Healing Erosive Esophagitis: Dexilant is approved for the treatment of erosive esophagitis, a condition where stomach acid damages the lining of the esophagus.
Maintenance of Healed Erosive Esophagitis: It is also used to maintain healing and prevent relapse of erosive esophagitis.
Symptomatic GERD: Dexilant is effective in relieving heartburn and other symptoms associated with non-erosive reflux disease (NERD).
Dosage Forms and Strengths: Dexilant is available in capsule form, typically in two strengths: 30 mg and 60 mg. The dosage and duration of treatment depend on the specific condition being treated and the patient's response to therapy.
Pharmacokinetics:
Absorption: Dexilant is absorbed in the gastrointestinal tract, with peak plasma concentrations occurring at 1-2 hours and 4-5 hours after administration due to its dual-release mechanism.
Metabolism: It is extensively metabolized in the liver by the cytochrome P450 enzyme system, primarily CYP2C19 and CYP3A4.
Excretion: The metabolites are excreted primarily in the urine and feces.
Clinical Efficacy: Clinical trials have demonstrated the effectiveness of Dexilant in healing erosive esophagitis and providing symptom relief in patients with GERD. Studies have shown that Dexilant offers superior acid control compared to other PPIs, particularly in patients with persistent nighttime symptoms. Its dual-release formulation ensures consistent acid suppression, reducing the likelihood of symptom breakthrough.
Safety and Side Effects: Dexilant is generally well-tolerated, but like all medications, it may cause side effects. Common side effects include:
Headache
Abdominal pain
Nausea
Diarrhea
Gas
Serious but rare side effects may include:
Increased risk of bone fractures (with long-term use)
Vitamin B12 deficiency (with prolonged use)
Clostridium difficile-associated diarrhea
Kidney disease (rare cases of acute interstitial nephritis)
Contraindications and Precautions:
Dexilant should not be used in patients with a known hypersensitivity to dexlansoprazole or any component of the formulation.
It is not recommended for use in patients taking rilpivirine-containing products due to potential drug interactions.
Long-term use of PPIs like Dexilant may increase the risk of certain conditions, such as osteoporosis-related fractures, hypomagnesemia, and infections.
Drug Interactions: Dexilant may interact with other medications, including:
Warfarin: Increased risk of bleeding.
Methotrexate: Reduced elimination of methotrexate, increasing toxicity.
Clopidogrel: Reduced effectiveness of clopidogrel due to CYP2C19 inhibition.
Antifungal and HIV medications: Potential interactions due to CYP3A4 metabolism.
Special Populations:
Pregnancy and Lactation: Dexilant should be used during pregnancy only if clearly needed. It is not known whether dexlansoprazole is excreted in breast milk.
Pediatric Use: Safety and efficacy in children have not been established.
Geriatric Use: No dose adjustment is necessary for elderly patients, but caution is advised due to potential age-related kidney impairment.
Conclusion: Dexilant (dexlansoprazole) is a highly effective proton pump inhibitor that provides sustained acid suppression through its innovative dual delayed-release formulation. It is widely used for the treatment and maintenance of GERD-related conditions, offering relief from symptoms and promoting healing of esophageal damage. While generally safe, patients should be monitored for potential side effects and drug interactions, especially with long-term use. As with any medication, Dexilant should be used under the guidance of a healthcare professional to ensure optimal therapeutic outcomes.
Dexlansoprazole pill
What is dexlansoprazole?
Heartburn brought on by gastroesophageal reflux disease (GERD) can be treated with dexlansoprazole, and the medication can also be used to mend erosive esophagitis (damage to the esophagus from stomach acid).
There are further applications for dexlansoprazole that have not been included in this pharmaceutical guide.
Warnings
Dexlansoprazole might cause renal issues. If you notice that you are peeing less than normal or that there is blood in your urine, you should consult your physician.
It's possible that a new infection is the cause of your diarrhea. If you experience diarrhea that is watery or contains blood, you should contact your doctor right once.
It's possible that taking dexlansoprazole can bring on new lupus symptoms or make existing ones worse. Talk to your primary care physician if you experience joint discomfort in addition to a skin rash on your face or arms that gets worse in the sun.
If you use dexlansoprazole for an extended period of time or more than once daily, you may increase your risk of breaking a bone.
Before beginning to use this medication
The early warning signs of a heart attack may be similar to those of heartburn. You should seek immediate medical attention if you are experiencing chest discomfort that has moved to your jaw or shoulder, as well as if you are feeling nervous or lightheaded.
You should not use this medication if you are allergic to dexlansoprazole, or if you have ever experienced difficulty breathing, renal problems, or a severe allergic response after taking this medication; or if you are simultaneously taking another medication that includes rilpivirine (Complera, Edurant, Odefsey).
In the past, have you ever been diagnosed with severe liver illness, osteoporosis, poor bone mineral density (osteopenia), or low levels of magnesium in your blood? If so, you should discuss this with your doctor.
If you use a proton pump inhibitor for an extended period of time or more than once per day, you may put yourself at an increased risk of breaking a bone in your hip, wrist, or spine. Have a discussion with your primary care provider about the best strategies to maintain the health of your bones.
It is possible for dexlansoprazole to cause damage to an unborn child. Always consult your physician if you become pregnant and be sure you use an effective method of birth control to avoid becoming pregnant in the first place.
When using this medication, it is possible that breastfeeding will not be a healthy option. Talk to your physician about any potential dangers.
Because of safety concerns, dexlansoprazole should not be used by anybody less than 12 years old.
What is the correct way to take dexlansoprazole?
Read all of the medication guides or instruction papers that come with your medicine, and make sure to follow all of the guidelines that are included on the prescription label. Always follow the directions on the label while taking medication.
While taking dexlansoprazole, be sure to drink a full glass of water with it.
It is possible to take dexlansoprazole either with or without meals.
Take the capsule as directed, without crushing, chewing, breaking, or opening it in any other way.
If you find that you are unable to take a capsule in its whole, you can open it and sprinkle the drug into some applesauce instead. Immediately and without chewing, ingest the concoction in its whole. Do not put it aside for use at a later time.
In order to treat erosive esophagitis and provide relief from heartburn, dexlansoprazole is often administered to adults for up to six months, and to youth aged 12 through 17 for between four and sixteen weeks. Always adhere to the dose directions provided by your physician.
Even if you feel better fast, you should continue to take this medication for the full amount of time that was given to you.
When you are on dexlansoprazole, you should contact your physician if your symptoms do not improve or if they become worse.
Some medical tests can provide different findings if you use this medication. Be sure that any medical professional who treats you is aware that you are taking dexlansoprazole.
There is a possibility that taking dexlansoprazole can skew the results of a urine test used to check for drugs. Inform the personnel working in the laboratory that you take dexlansoprazole.
Keep at room temperature and away from heat and moisture when storing.
While I am under the influence of dexlansoprazole, what should I try to steer clear of?
Diarrhea, which might be an indication of a new infection, can be caused by the medication dexlansoprazole. You should seek medical attention if you experience diarrhea that is watery or bloody. If your doctor has not instructed you to do so, you should not take any medicine to treat diarrhea.
Dexlansoprazole side effects
You should seek immediate medical attention if you have the following symptoms of an allergic reaction: hives; trouble breathing; swelling of your face, lips, tongue, or neck.
In the event that you are experiencing severe stomach pain, diarrhea that is watery or bloody; a seizure (convulsions); sudden pain or difficulty moving your hip, wrist, or back; kidney problems � fever, rash, nausea, loss of appetite, joint pain, urinating less than usual, blood in your urine, weight gain; low magnesium � dizziness, fast or irregular heart rate, tremors (shaking) or jerking muscle movements, feeling jittery, muscle
If you use dexlansoprazole for an extended period of time, you run the risk of developing stomach growths known as fundic gland polyps. Have a discussion about this danger with your attending physician.
It is possible to become deficient in vitamin B-12 if you use dexlansoprazole for a period of time longer than three years. Speak to your primary care physician about the best treatment options for you if you do end up with this illness.
The following are examples of common adverse effects that may occur: nausea, vomiting, stomach discomfort, gas; diarrhea; headache; mouth pain; sore throat; stuffy nose, sinus pain; or other cold symptoms.
What other medications might potentially interact with dexlansoprazole?
Inform your doctor about any and all medications you are currently taking. There are a number of medications that can interact with dexlansoprazole, the most notable of which being methotrexate, rifampin, St. John's wort, and warfarin (Coumadin, Jantoven).
This list is not exhaustive, and the effects of dexlansoprazole may also be influenced by many other medications. This include both prescription and over-the-counter medications, in addition to herbal and vitamin supplements. This page does not provide a complete listing of all possible medication interactions.
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try out a different kind and see if it was a better fit for my needs. Which it was!
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crossed my mind how much cheaper the generic versions were. When I started browsing the
items I couldn’t believe the price difference! This is my go to shop right now.
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always bought it in store. I spoke to one of their support reps and they were really nice
and helped to explain how it works and made me feel much more comfortable with my order!
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and it definitely won’t be my last! They had all the items I needed in one place and the
prices are the best I could find online.
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