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Dexilant

Cardiovascular Diseases Dexilant (Generic) Generic drugs, marketed without brand names, contain the exact same active ingredients used in their brand-name counterparts, but cost significantly less. The drugs are required to meet US Food and Drug Administration (FDA) standards for safety, purity and effectiveness.
Dexilant

Heartburn brought on by gastroesophageal reflux disease (GERD) can be treated with dexlansoprazole, and the medication can also be used to mend erosive esophagitis (damage to the esophagus from stomach acid).

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Overview of Dexilant (Dexlansoprazole)

Introduction:
Dexilant, known generically as dexlansoprazole, is a proton pump inhibitor (PPI) used to treat conditions related to excessive stomach acid production. It is commonly prescribed for gastroesophageal reflux disease (GERD), including erosive esophagitis and non-erosive reflux disease (NERD), as well as for the maintenance of healed erosive esophagitis. Dexilant is a modified-release formulation of lansoprazole, designed to provide prolonged acid suppression and improved symptom relief.


Mechanism of Action:
Dexilant works by inhibiting the hydrogen-potassium adenosine triphosphatase (H+/K+ ATPase) enzyme system, also known as the proton pump, located on the secretory surface of gastric parietal cells. By blocking this enzyme, Dexilant reduces the production of gastric acid, thereby decreasing acidity in the stomach. This mechanism helps alleviate symptoms such as heartburn, regurgitation, and stomach discomfort associated with acid-related disorders.


Key Features:

  1. Dual Delayed-Release Technology:
    Dexilant utilizes a unique dual delayed-release formulation, which allows for two separate releases of the medication. The first release occurs within 1-2 hours after ingestion, and the second release occurs 4-5 hours later. This design provides prolonged acid suppression over a 24-hour period, making it effective for managing both daytime and nighttime symptoms.

  2. Indications:

    • Healing Erosive Esophagitis: Dexilant is approved for the treatment of erosive esophagitis, a condition where stomach acid damages the lining of the esophagus.

    • Maintenance of Healed Erosive Esophagitis: It is also used to maintain healing and prevent relapse of erosive esophagitis.

    • Symptomatic GERD: Dexilant is effective in relieving heartburn and other symptoms associated with non-erosive reflux disease (NERD).

  3. Dosage Forms and Strengths:
    Dexilant is available in capsule form, typically in two strengths: 30 mg and 60 mg. The dosage and duration of treatment depend on the specific condition being treated and the patient's response to therapy.


Pharmacokinetics:

  • Absorption: Dexilant is absorbed in the gastrointestinal tract, with peak plasma concentrations occurring at 1-2 hours and 4-5 hours after administration due to its dual-release mechanism.

  • Metabolism: It is extensively metabolized in the liver by the cytochrome P450 enzyme system, primarily CYP2C19 and CYP3A4.

  • Excretion: The metabolites are excreted primarily in the urine and feces.


Clinical Efficacy:
Clinical trials have demonstrated the effectiveness of Dexilant in healing erosive esophagitis and providing symptom relief in patients with GERD. Studies have shown that Dexilant offers superior acid control compared to other PPIs, particularly in patients with persistent nighttime symptoms. Its dual-release formulation ensures consistent acid suppression, reducing the likelihood of symptom breakthrough.


Safety and Side Effects:
Dexilant is generally well-tolerated, but like all medications, it may cause side effects. Common side effects include:

  • Headache

  • Abdominal pain

  • Nausea

  • Diarrhea

  • Gas

Serious but rare side effects may include:

  • Increased risk of bone fractures (with long-term use)

  • Vitamin B12 deficiency (with prolonged use)

  • Clostridium difficile-associated diarrhea

  • Kidney disease (rare cases of acute interstitial nephritis)


Contraindications and Precautions:

  • Dexilant should not be used in patients with a known hypersensitivity to dexlansoprazole or any component of the formulation.

  • It is not recommended for use in patients taking rilpivirine-containing products due to potential drug interactions.

  • Long-term use of PPIs like Dexilant may increase the risk of certain conditions, such as osteoporosis-related fractures, hypomagnesemia, and infections.


Drug Interactions:
Dexilant may interact with other medications, including:

  • Warfarin: Increased risk of bleeding.

  • Methotrexate: Reduced elimination of methotrexate, increasing toxicity.

  • Clopidogrel: Reduced effectiveness of clopidogrel due to CYP2C19 inhibition.

  • Antifungal and HIV medications: Potential interactions due to CYP3A4 metabolism.


Special Populations:

  • Pregnancy and Lactation: Dexilant should be used during pregnancy only if clearly needed. It is not known whether dexlansoprazole is excreted in breast milk.

  • Pediatric Use: Safety and efficacy in children have not been established.

  • Geriatric Use: No dose adjustment is necessary for elderly patients, but caution is advised due to potential age-related kidney impairment.


Conclusion:
Dexilant (dexlansoprazole) is a highly effective proton pump inhibitor that provides sustained acid suppression through its innovative dual delayed-release formulation. It is widely used for the treatment and maintenance of GERD-related conditions, offering relief from symptoms and promoting healing of esophageal damage. While generally safe, patients should be monitored for potential side effects and drug interactions, especially with long-term use. As with any medication, Dexilant should be used under the guidance of a healthcare professional to ensure optimal therapeutic outcomes.

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