Antibiotics, Eye CareBesivance (Generic)
Generic drugs, marketed without brand names, contain the exact same active ingredients used in their brand-name counterparts, but cost significantly less. The drugs are required to meet US Food and Drug Administration (FDA) standards for safety, purity and effectiveness.
Besivance
Besivance ophthalmic is prescribed to patients who have bacterial infections of the eye. Besifloxacin is an antibiotic that is classified as a member of the quinolone family of medicines. It achieves its effect by inhibiting the development of microorganisms. Only bacterial eye infections may be treated with this particular medicine. It is not effective for treating any other kinds of eye infections (such as infections caused by viruses, fungi, mycobacteria).
Besivance (Besifloxacin Ophthalmic Suspension): A Comprehensive Overview
Introduction: Besivance (besifloxacin ophthalmic suspension) is a topical ophthalmic antibiotic used to treat bacterial infections of the eye. It belongs to the fluoroquinolone class of antibiotics, which are known for their broad-spectrum antibacterial activity. Besivance is specifically formulated for ocular use and is prescribed to treat bacterial conjunctivitis, commonly referred to as "pink eye." This medication is notable for its efficacy, safety profile, and unique formulation, which enhances its ability to combat bacterial infections effectively.
Mechanism of Action: Besivance contains besifloxacin, a fluoroquinolone antibiotic that works by inhibiting bacterial DNA gyrase and topoisomerase IV, two enzymes essential for bacterial DNA replication, transcription, and repair. By targeting these enzymes, besifloxacin effectively prevents the growth and proliferation of bacteria, leading to their eventual death. This mechanism of action makes Besivance effective against a wide range of gram-positive and gram-negative bacteria, including strains that are resistant to other antibiotics.
Indications: Besivance is primarily indicated for the treatment of bacterial conjunctivitis caused by susceptible strains of bacteria. Bacterial conjunctivitis is a common eye infection characterized by redness, swelling, discharge, and discomfort. The condition can affect individuals of all ages, including children and adults. Besivance is particularly useful in cases where the infection is caused by bacteria that are resistant to other antibiotics.
Dosage and Administration: Besivance is available as a 0.6% ophthalmic suspension. The typical dosage for adults and children one year of age and older is one drop in the affected eye(s) three times daily, spaced approximately 4 to 12 hours apart, for 7 days. It is important to follow the prescribed dosing regimen and complete the full course of treatment, even if symptoms improve before the medication is finished. This helps to ensure the infection is fully eradicated and reduces the risk of antibiotic resistance.
Before administering Besivance, patients should wash their hands thoroughly to avoid contaminating the eye or the medication bottle. The tip of the dropper should not touch the eye, fingers, or any other surface to prevent contamination. If using other eye medications, patients should wait at least 5 minutes between applying different eye drops.
Pharmacokinetics: Besivance is designed for topical ocular use, and systemic absorption is minimal. The drug remains localized to the eye, where it exerts its antibacterial effects. Studies have shown that besifloxacin achieves high concentrations in the conjunctiva and cornea, the primary sites of infection in bacterial conjunctivitis. This localized action minimizes the risk of systemic side effects and enhances the drug's efficacy.
Safety and Side Effects: Besivance is generally well-tolerated, with most side effects being mild and transient. Common side effects may include:
Eye irritation or discomfort
Blurred vision
Redness
Dryness
Headache
Serious side effects are rare but may include allergic reactions, such as itching, swelling, or severe redness. If any severe or persistent side effects occur, patients should discontinue use and consult their healthcare provider immediately.
Contraindications and Precautions: Besivance is contraindicated in individuals with a known hypersensitivity to besifloxacin or any other component of the formulation. Patients should inform their healthcare provider if they have a history of allergic reactions to fluoroquinolones or other antibiotics.
While Besivance is considered safe for use in children aged one year and older, its safety and efficacy in infants under one year have not been established. Pregnant or breastfeeding women should consult their healthcare provider before using Besivance, as the potential risks to the fetus or infant are not fully understood.
Advantages of Besivance:
Broad-Spectrum Activity: Besivance is effective against a wide range of bacterial pathogens, including multidrug-resistant strains.
Localized Action: Its topical formulation ensures high concentrations at the site of infection with minimal systemic absorption.
Convenience: The three-times-daily dosing regimen is easy to follow and improves patient compliance.
Low Risk of Resistance: Besifloxacin's unique chemical structure reduces the likelihood of bacterial resistance compared to other fluoroquinolones.
Clinical Efficacy: Clinical trials have demonstrated the efficacy of Besivance in treating bacterial conjunctivitis. In studies, patients treated with Besivance showed significant improvement in symptoms such as redness, discharge, and discomfort compared to those receiving a placebo. The medication was also effective in eradicating the causative bacteria, leading to a high rate of clinical cure.
Comparison with Other Ophthalmic Antibiotics: Besivance is often compared to other ophthalmic antibiotics, such as moxifloxacin, gatifloxacin, and azithromycin. While these medications are also effective in treating bacterial conjunctivitis, Besivance offers several advantages, including its broad-spectrum activity and low potential for resistance. Additionally, its unique formulation allows for prolonged contact with the ocular surface, enhancing its therapeutic effect.
Patient Education: Patients using Besivance should be educated on proper administration techniques and the importance of completing the full course of treatment. They should also be advised to avoid wearing contact lenses while experiencing symptoms of bacterial conjunctivitis, as lenses can exacerbate the infection and interfere with the medication's effectiveness. If contact lens use is necessary, patients should wait at least 15 minutes after administering Besivance before inserting their lenses.
Conclusion: Besivance (besifloxacin ophthalmic suspension) is a highly effective and well-tolerated treatment for bacterial conjunctivitis. Its broad-spectrum antibacterial activity, localized action, and convenient dosing regimen make it a valuable option for patients and healthcare providers. By adhering to the prescribed treatment plan and following proper administration guidelines, patients can achieve rapid relief from symptoms and a successful resolution of the infection. As with any medication, patients should consult their healthcare provider with any questions or concerns about using Besivance.
This comprehensive overview highlights the key aspects of Besivance, from its mechanism of action to its clinical efficacy and patient considerations. It serves as a valuable resource for understanding the role of Besivance in the management of bacterial eye infections.
Ophthalmic use of Besivance
What exactly is the besivance?
Besivance, also known as besifloxacin, is an antibiotic that is classified as a member of the fluoroquinolone class. The antibacterial agent besifloxacin eliminates microorganisms from the body.
Besivance is an antibacterial medicine that is prescribed to patients who have been diagnosed with ocular bacterial infections.
Moreover, this medication guide does not include all of the possible applications for Besivance.
Information That Is Vital
If you have ever had an allergic reaction to besifloxacin, you should not take Besivance.
Use this medicine precisely as your healthcare provider has instructed you to. It is not suggested to use it in greater quantities or for a longer period of time than is stated above. Be sure to take your medication exactly as directed on the label.
Besivance users may have serious adverse effects such as eye discharge or crusting, acute eye irritation, the sensation that there is something in their eye, eye redness or swelling, fever, or any symptoms that an infection has developed.
Make sure to keep taking Besivance for the whole amount of time that has been recommended. It's possible that your symptoms will go better before the virus is totally gone.
It is important that you do not take this medicine if you are going to be wearing contact lenses. This drug could have a preservative, and soft contact lenses have the potential to take in that preservative. Besivance should be used once, and then you should wait at least 15 minutes before inserting your contact lenses.
While you still have active symptoms of the eye infection you are treating, you should not wear contact lenses. This is for your own safety.
Before beginning to use this medication
If you have ever had an allergic reaction to besifloxacin, you should not take Besivance.
Before beginning therapy with this medicine, you should discuss your pregnancy or your plans to get pregnant with your attending physician. It is unknown whether or not besifloxacin makes its way into breast milk or whether or not it might cause damage to a breastfeeding infant. If you are a breastfeeding mother, you should not take Besivance without first seeing your physician.
What is the best way for me to utilize Besivance?
Always follow your physician's instructions while applying the Besivance eye drops. Read all of the medication guides or instruction papers that come with your medicine, and make sure to follow all of the guidelines that are included on the prescription label.
If you are currently using soft contact lenses, you should not use. This drug contains a preservative that may leave a persistent stain on the lenses. At a minimum of 15 minutes before placing your contact lenses, you should take the medication.
Always remember to wash your hands before administering any eye medicine.
Besivance eye drops should be applied as follows:
Before each use, invert the bottle so that the label is facing down, and shake it once.
Create a little pocket under your lower eyelid by tilting your head back slightly and pulling down on your lower eyelid. Keep the tip of the dropper pointing away from the eye as you hold it above your eye. Close your eye once you've extracted a drop from the dropper and look away from it in the opposite direction.
To prevent the liquid from flowing into your tear duct, place the tip of your finger in the inner corner of your eye and gently push there for about a minute. This will be near your nose.
It is important to ensure that the tip of the dropper does not come into contact with any surface, especially the eyes or the hands. If the dropper becomes contaminated, it has the potential to induce an infection in your eye, which, if left untreated, might result in permanent vision loss or other significant eye damage.
Use this medication for the entire amount of time that is recommended by your doctor. It's possible that your symptoms will go better before the virus is totally gone. Missing doses of medicine puts you at a greater risk of developing an illness that is resistant to treatment.
Keep this medication in an upright position at room temperature, away from moisture and heat, and take care not to crush or shake it. While not in use, ensure that the cap is securely fastened on the bottle.
Information on the dosage of Besivance
Typical Adult Dosage for Bacterial Conjunctivitis:
Instill one drop into the eye or eyes that are afflicted three times a day at intervals ranging from four to twelve hours over the next seven days.
Indications for use: For the treatment of bacterial conjunctivitis caused by susceptible isolates of Aerococcus viridans, CDC coryneform group G, Corynebacterium pseudodiphtheriticum, C striatum, Haemophilus influenzae, Moraxella lacunata, M catarrhalis, Pseudomonas aeruginosa, Staphylococcus aureus, S epidermidi
In children, the typical dose for bacterial conjunctivitis is as follows:
1 year or older: Instill one drop into the eye or eyes that are afflicted three times a day at intervals ranging from four to twelve hours over the next seven days.
Utilization: For the treatment of bacterial conjunctivitis caused by susceptible isolates of A. viridans, CDC coryneform group G, C. pseudodiphtheriticum, C. striatum, H. influenzae, M. lacunata, M. catarrhalis, P. aeruginosa, S. aureus, S. epidermidis, S. hominis, S. lugdunensis, S.
What can I expect if I forget to take a dose?
Take the medication as soon as it is convenient for you to do so, but avoid the missed dose if it is almost time for your next scheduled dosage. It is not recommended to take two dosages at once.
What happens if I overdose?
It is not anticipated that a high dose of Besivance would cause any adverse effects. If anybody has unintentionally ingested the medicine, seek immediate medical assistance or contact the Poison Help line at 1-800-222-1222 for further information.
When I am using Besivance, what should I try not to do?
If you are currently using contact lenses, you should avoid using the Besivance eye drops. There is a possibility that Besivance contains a preservative that is capable of being taken in by soft contact lenses. After administering the medicine, you should hold off on putting your contact lenses in for at least 15 minutes.
While you still have active symptoms of the eye infection you are treating, you should not wear contact lenses. This is for your own safety.
Besivance side effects
Seek immediate medical attention if you experience any of the following symptoms after taking Besivance: hives, difficulty breathing, and swelling of the face, lips, tongue, or neck are all symptoms of anaphylaxis.
If you have any of the following symptoms, you should contact your doctor as soon as possible: eye drainage or crusting; severe eye irritation after using the eye drops; the sensation that there is something in your eye; severe eye redness or swelling; fever; or any signs that indicate you may have developed a new infection.
Besivance users may experience common side effects such as eye redness.
Which additional substances will have an effect on Besivance?
It is not expected that the medicine you put in your eyes will interact negatively with any other medications you take. Yet, many different medications might have an effect on one another. Inform each of your healthcare providers about any and all medications you use, whether they are prescribed to you or purchased over the counter, as well as any vitamins or herbal supplements you take.
More details may be found here.
Be sure to keep Besivance and any other medication out of the reach of minors at all times, never lend your medications to anyone else, and use Besivance for the sole purpose of treating the condition for which it was given.
Please check with your doctor or other healthcare professional to confirm that the information contained on this page is applicable to your specific situation before acting upon it.
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