Kombiglyze® XR

Metformin and saxagliptin are two types of medications. Oral diabetic medications like metformin and saxagliptin are both effective in bringing blood sugar levels under control. Metformin is able to achieve its therapeutic effect by inhibiting the generation of glucose (sugar) in the liver as well as the intestinal absorption of glucose. Saxagliptin is effective because it controls the amount of insulin that is produced by your body in response to eating. Adults who have type 2 diabetes mellitus may benefit from taking a combination medication consisting of metformin and saxagliptin, in addition to maintaining a healthy diet and engaging in regular physical activity. This medication is not intended for use in the treatment of diabetes type 1. In addition to the applications described in this pharmaceutical guide, metformin and saxagliptin may also be utilized for other purposes. Information That Is Vital If you have severe renal disease or diabetic ketoacidosis, you should not use this drug (call your doctor for treatment with insulin). Using metformin has been linked in certain cases to the development of lactic acidosis. The initial symptoms may progress to a more severe state over time, and this ailment can ultimately be deadly. If you have any symptoms, even if they are slight, such as muscular pain or weakness, difficulty breathing, stomach discomfort, nausea, and feeling very weak or weary, you should immediately stop taking this prescription and get emergency medical treatment. Before beginning to use this medication If you have severe renal disease or diabetic ketoacidosis, you should not take this drug. Furthermore, if you are allergic to metformin or saxagliptin (Onglyza), you should not use this medicine (call your doctor for treatment with insulin). Those who use metformin may be more likely to develop lactic acidosis, a potentially fatal illness. If you have liver or renal illness, congestive heart failure, a history of a heart attack or stroke, a severe infection, if you are over the age of 65, if you are dehydrated, or if you use a lot of alcohol, your risk of developing this condition may be increased. Discuss your risk with your attending physician. Tell your doctor if you have any of the following conditions: kidney disease (your kidney function may need to be checked before you take this medicine); liver disease; heart disease; pancreatitis; high triglycerides (a type of fat in the blood); gallstones; a history of alcoholism; or if you are over 80 years old and have not recently had your kidney function checked. This will ensure that metformin and saxagliptin is safe for you to take. You will be required to temporarily cease taking metformin and saxagliptin if you are about to undergo surgery, any sort of x-ray or CT scan utilizing a dye that is injected into your veins, or any other procedure that uses a dye. Make sure that your carers are aware that you are going to be taking this medicine in advance. It is not anticipated that this medication will cause any damage to an unborn child. Inform your physician if you are pregnant or if you want to become pregnant in the near future. It is unknown whether this medication is excreted into breast milk or whether it might cause damage to a baby who is being breastfed. If you are breastfeeding a child, you should let your doctor know about it. The use of this medication by anybody under the age of 18 is not permitted by the manufacturer. What is the correct way for me to take metformin with saxagliptin? Always make sure to follow all of the instructions on the label of your medication. Do not use this medication in greater or lower doses than indicated, nor for a longer period of time than specified. Metformin and saxagliptin should be taken in conjunction with a meal. An extended-release tablet should not be chewed, crushed, or broken in any way. Take it in its entirety. Hypoglycemia, often known as low blood sugar, is something that can affect anyone who has diabetes. Headache, hunger, perspiration, irritability, dizziness, nausea, rapid heart rate, and feelings of unease or shakiness are some of the symptoms that may be experienced. Have a quick-acting supply of sugar on you at all times, such as fruit juice, hard candies, crackers, raisins, or regular soda, in order to swiftly correct low blood sugar. This may be accomplished by always having a source of sugar on hand. In the event that you suffer from severe hypoglycemia and are unable to eat or drink, your doctor may prescribe a glucagon emergency injection kit for you to utilize. Be sure that your immediate family and any close friends you have know how to administer this injection in the event of a medical emergency. Be on the lookout for symptoms of hyperglycemia (high blood sugar), including increased thirst or urination, blurred vision, headache, and exhaustion. If you become unwell, have a fever or infection, or if you are about to have surgery or a medical emergency, your doctor may recommend that you stop taking this prescription for a brief period of time. Stress, sickness, surgery, physical activity, use of alcoholic beverages, and missing meals are all factors that might influence one's blood sugar levels. Before making any adjustments to your dosage or drug plan, check in with your primary care physician. This medication is simply one component of a comprehensive treatment plan that may include involve changes to one's diet and exercise routine, as well as regular blood testing, foot care, and eye care. Be very careful to adhere to the prescribed regimens for your medicine, nutrition, and exercise. Keep at room temperature and away from heat and moisture when storing. What can I expect if I forget to take a dose? When you realize that you missed a dosage, take it as soon as you can (be sure to take the medicine with food). If it is almost time for your next scheduled dosage, you should skip the dose that you missed. It is not necessary to take additional medication in order to make up for a missed dosage. While I'm on metformin and saxagliptin, are there any foods or activities I should avoid? Avoid consuming alcohol. It causes a drop in blood sugar and can make you more susceptible to lactic acidosis. Effects of metformin and saxagliptin on the body If you are experiencing symptoms of an allergic response, such as hives, trouble breathing, or swelling of the face, lips, tongue, or throat, you should seek immediate medical attention. If you have signs of pancreatitis, including severe pain in your upper stomach that spreads to your back, nausea and vomiting, lack of appetite, or rapid heartbeats, you should immediately stop taking this prescription and contact your physician. Using metformin has been linked in certain cases to the development of lactic acidosis. The initial symptoms may progress to a more severe state over time, and this ailment can ultimately be deadly. Stop taking this medication immediately and contact an emergency medical service if you experience any symptoms, no matter how minor, including but not limited to: muscle pain or weakness; a tingling, numbing, or cold feeling in your arms and legs; difficulty breathing; feeling dizzy, lightheaded, tired, or very weak; stomach pain, nausea, or vomiting; or a slow or uneven heart rate. If you experience a severe autoimmune reaction, including itching, blistering, or the destruction of the outer layer of your skin; severe or chronic discomfort in your joints; pain or burning when you pee; pain in your joints; or heart issues, you should contact your doctor as soon as possible. �a fast increase in weight, edema, shortness of breath (even while lying down), feelings of weakness or fatigue (especially in your feet, legs, or midsection). The following are examples of common adverse reactions that may occur as a result of taking this medication: diarrhea, moderate nausea; headache; or cold symptoms such as runny or stuffy nose, sneezing, or sore throat. This list of potential adverse effects is not exhaustive; additional symptoms may also surface. Make an appointment with your primary care physician to discuss any adverse effects. What other medications besides metformin and saxagliptin could have an effect on you? Metformin and saxagliptin might potentially interact with a wide variety of other medications. Metformin and saxagliptin may not regulate your blood sugar as well as they would otherwise if you are also taking other medications. The chance of developing lactic acidosis may be increased if you use other medications. Talk to your primary care physician about all of the medications you are currently taking, as well as any new medications or ones you stop taking, particularly antibiotics or antifungal drugs, insulin or oral diabetic treatments, or medicines used to treat HIV or AIDS. This list does not contain everything. There is a possibility that metformin and saxagliptin will interact negatively with other medications, such as prescription and over-the-counter pharmaceuticals, vitamins, and herbal treatments. This drug guide does not provide a description of all potentially harmful interactions.