DiabetesGlucovance (Generic)
Generic drugs, marketed without brand names, contain the exact same active ingredients used in their brand-name counterparts, but cost significantly less. The drugs are required to meet US Food and Drug Administration (FDA) standards for safety, purity and effectiveness.
Glucovance
The treatment of diabetes type 2 with generic Glucovance is currently available. In addition to a healthy diet and regular exercise, it is recommended. You can take it by itself or in combination with another diabetes medication.
Generic Glucovance is a combination medication that contains two active ingredients: glyburide (a sulfonylurea) and metformin (a biguanide). It is primarily used to manage blood sugar levels in individuals with type 2 diabetes. This combination therapy leverages the complementary mechanisms of action of both drugs to provide more effective glycemic control than either drug could achieve alone. This article provides an in-depth look at generic Glucovance, including its mechanism of action, indications, dosage, side effects, contraindications, and more.
Mechanism of Action
Generic Glucovance combines the effects of glyburide and metformin to improve glycemic control through different mechanisms:
Glyburide: Glyburide is a second-generation sulfonylurea that stimulates the beta cells of the pancreas to release insulin. It works by closing ATP-sensitive potassium channels in the pancreatic beta cells, leading to cell depolarization and subsequent insulin secretion. This helps to lower blood glucose levels by increasing the amount of insulin available to facilitate glucose uptake by cells.
Metformin: Metformin works primarily by decreasing hepatic glucose production (gluconeogenesis) and increasing insulin sensitivity in peripheral tissues, such as muscle and fat. It also enhances glucose uptake by these tissues and reduces glucose absorption from the gastrointestinal tract. Unlike sulfonylureas, metformin does not stimulate insulin secretion and therefore carries a lower risk of hypoglycemia.
Indications
Generic Glucovance is indicated for the management of type 2 diabetes mellitus in patients who cannot achieve adequate glycemic control with diet and exercise alone. It is particularly useful for patients who may benefit from the combined effects of glyburide and metformin. Glucovance is not indicated for type 1 diabetes or diabetic ketoacidosis, as these conditions require insulin therapy.
Dosage and Administration
The dosage of generic Glucovance is individualized based on the patient's current treatment regimen, glycemic control, and other factors such as renal function. The medication is available in several fixed-dose combinations, including:
Glyburide 1.25 mg / Metformin 250 mg
Glyburide 2.5 mg / Metformin 500 mg
Glyburide 5 mg / Metformin 500 mg
The usual starting dose is one or two tablets of the lowest strength (1.25 mg/250 mg) taken once or twice daily with meals. The dose may be gradually increased based on blood glucose levels, with a maximum recommended dose of glyburide 20 mg / metformin 2000 mg per day. It is important to take Glucovance with meals to reduce the risk of gastrointestinal side effects.
Side Effects
Generic Glucovance can cause side effects, although not everyone experiences them. Common side effects include:
Hypoglycemia (low blood sugar): Symptoms may include dizziness, sweating, confusion, and hunger. Hypoglycemia is more likely to occur with the glyburide component.
Gastrointestinal issues: Nausea, vomiting, diarrhea, and abdominal discomfort are common, particularly with the metformin component. These symptoms often subside with continued use.
Weight gain: Some patients may experience weight gain due to the glyburide component.
Metallic taste: A metallic taste in the mouth is a less common side effect associated with metformin.
Less common but more serious side effects include:
Lactic acidosis: A rare but serious condition associated with metformin, particularly in patients with renal impairment. Symptoms include muscle pain, difficulty breathing, stomach discomfort, and feeling cold.
Hematologic effects: Such as megaloblastic anemia due to vitamin B12 deficiency, which can occur with long-term metformin use.
Liver dysfunction: Rare cases of hepatitis and jaundice have been reported with glyburide.
Contraindications
Generic Glucovance is contraindicated in patients with:
Known hypersensitivity to glyburide, metformin, or any other component of the medication.
Type 1 diabetes or diabetic ketoacidosis.
Severe renal impairment (e.g., serum creatinine levels ≥1.5 mg/dL in men or ≥1.4 mg/dL in women, or abnormal creatinine clearance).
Patients taking generic Glucovance should be closely monitored for signs of hypoglycemia, especially those who are elderly, malnourished, or have adrenal or pituitary insufficiency. Regular monitoring of renal function is essential, as metformin is excreted by the kidneys and renal impairment can increase the risk of lactic acidosis. Additionally, patients should be advised to avoid excessive alcohol consumption, as it can increase the risk of lactic acidosis and hypoglycemia.
Drug Interactions
Generic Glucovance can interact with a variety of medications, potentially altering its effectiveness or increasing the risk of side effects. Some notable interactions include:
Beta-blockers: These can mask the symptoms of hypoglycemia.
Corticosteroids: These can increase blood sugar levels, counteracting the effects of Glucovance.
Diuretics: Thiazide diuretics can reduce the effectiveness of glyburide.
NSAIDs: Nonsteroidal anti-inflammatory drugs can increase the risk of hypoglycemia.
Iodinated contrast agents: These should be avoided in patients taking metformin due to the increased risk of lactic acidosis.
Special Populations
Pregnancy and Lactation: Glucovance is generally not recommended during pregnancy, as it can cause neonatal hypoglycemia. Insulin is the preferred treatment for managing diabetes during pregnancy. It is also not recommended for use in breastfeeding women.
Elderly Patients: Elderly patients may be more susceptible to hypoglycemia and should be started on a lower dose of Glucovance. Renal function should be closely monitored.
Pediatric Patients: The safety and efficacy of Glucovance in children have not been established.
Conclusion
Generic Glucovance (glyburide and metformin) is a valuable combination medication in the management of type 2 diabetes, offering an effective means of controlling blood sugar levels through complementary mechanisms of action. However, like all medications, it must be used with caution, and patients should be closely monitored for potential side effects and interactions. By understanding the full scope of Glucovance's benefits and risks, healthcare providers can better tailor treatment plans to meet the individual needs of their patients, ultimately improving outcomes and quality of life for those living with diabetes.
Tablet containing glibenclamide and metformin
What kind of medication is this?
Both GLIBENCLAMIDE and METFORMIN are beneficial in the treatment of type 2 diabetes. Diet and exercise are also components of the treatment plan. Your body will be able to make better utilization of insulin as a result of taking the medication.
Before I start using this medication, what should I discuss with my primary care physician?
People have a right to know if you suffer from any of the following conditions:
diabetic ketoacidosis
coronary artery disease
diseases of the kidneys and liver, as well as serious infections and injuries
illness of the thyroid
a response that is out of the ordinary or allergic to glyburide, sulfa medications, other medicines, foods, colors, or preservatives
pregnant or attempting to get pregnant
breast-feeding
What is the correct way to take this medication?
This medication should be taken orally with a full glass of water. If you only need to take this medication once daily, take it in the morning, preferably with breakfast or the first major meal of the day. Always remember to take your medication at the same time every day. Use this medication exactly as advised, and no more.
Have a discussion with your child's physician about the possibility of giving them this medication. It's possible that further attention is required.
Those over the age of 65 who are considered elderly may have a more severe response and so require a lower dosage.
In the event that you believe you may have taken an excessive amount of this medication, you should immediately contact a poison control center or an emergency facility.
PLEASE TAKE NOTE That no one else should use this medication. It is important that others not use this medication.
What should I do if I forget a dose?
If you forget to take a dosage, you should take it as soon as you remember it. Take only that dose if it is getting close to the time for your next scheduled dose. Do not take duplicate or additional dosages.
What other substances could react with this medication?
bosentan\schloramphenicol
Medications containing cisapride for the treatment of yeast or fungal infections
metoclopramide
probenecid\swarfarin
There are a variety of drugs that have the potential to raise or lower blood sugar levels. They include:
drinks with alcoholic content
aspirin and aspirin-like medications
female hormones, such as chloramphenicol and chromium, such as estrogens or progestins, as well as birth control pills
medications for the heart such as isoniazid and male hormones or anabolic steroids
medications for treating mental disorders medications for treating allergies, asthma, colds, or coughs medications for treating weight loss
medications referred to as MAO Inhibitors such as Nardil, Parnate, Marplan, and Eldepryl; niacin; nonsteroidal anti-inflammatory drugs (NSAIDs), which are medicines for pain and inflammation, such as ibuprofen or naproxen; pentamidine; phenytoin; probenecid; quinolone antibiotics such as ciprofloxacin, levofloxacin, and ofloxacin; some herbal dietary supplements;
steroids like prednisone or cortisone Thyroid medication Water tablets or diuretics Steroid drugs like prednisone or cortisone
It's probable that this list doesn't cover all of the possible interactions. Provide your primary care physician with a list of all the medications, herbs, over-the-counter pharmaceuticals, and dietary supplements that you are currently using. Additionally let them know whether you are a smoker, a drinker, or if you take any illicit substances. It's possible that certain things might react badly with your medication.
What side effects should I be on the lookout for when using this medication?
You should schedule frequent checkups with your primary care physician or another qualified medical expert. Get the skills necessary to monitor your blood sugar levels. If your blood sugar is high, you should discuss the matter with your physician or another qualified medical practitioner; you may need to adjust the dosage of your medication. It is possible that you will need to adjust the dosage of your medication if you are experiencing an illness or if you are exercising more than normal. Do not miss meals. Inquire with your primary care physician or another qualified health care provider about whether or not you should avoid alcohol. In the event that you have symptoms of low blood sugar, you should immediately consume something sweet by either eating or drinking it, and then get in touch with a medical practitioner. If you have severe symptoms of low blood sugar, such as seizures or unconsciousness, make sure that your loved ones are aware that you run the risk of choking if you eat or drink at this time and that they should seek immediate medical attention.
This medication has the potential to increase your sensitivity to the sun. Stay out of the direct sunlight. Wear protective gear and be sure to apply sunscreen if you can't help but be outside in the sun. Avoid using sun lamps as well as tanning beds and booths.
You should always have a card that details all the drugs you take with you and identify yourself with a medical identity bracelet or chain that indicates you have diabetes.
What potential negative reactions may I have to this medication?
You should report the following side effects to your physician or another qualified medical expert as soon as possible:
Symptoms of an allergic response might include a rash, itching, or hives on the skin; swelling of the face, lips, or tongue; and breathing difficulties.
dark urine\sfever, chills, sore throat
low blood sugar (ask your doctor or healthcare professional for a list of these symptoms)
bruising or bleeding that may not heal quickly yellowing of the eyes or skin
Adverse effects that, in most cases, do not need seeking medical attention (although you should let your doctor or another health care expert know if they persist or become bothersome):
diarrhea\sheadache
heartburn
nausea, vomiting
stomach discomfort
It's conceivable that this list doesn't cover all of the potential negative consequences.
Where should I store my medication, if you please?
Be sure that youngsters can't get their hands on it.
Keep at room temperature between 15 and 30 degrees C (59 and 86 degrees F). After the expiration date, any medicine that has been used should be thrown away.
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selection of products. I wasn’t happy with my current ED product was using, so I was able to
try out a different kind and see if it was a better fit for my needs. Which it was!
– John, Wellington
I have been buying brand meds name for years and it never
crossed my mind how much cheaper the generic versions were. When I started browsing the
items I couldn’t believe the price difference! This is my go to shop right now.
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I wasn’t quite sure about buying my medication online as I
always bought it in store. I spoke to one of their support reps and they were really nice
and helped to explain how it works and made me feel much more comfortable with my order!
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has all the best generic items at crazy good prices. I order here every month.
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It was my first time ordering at
and it definitely won’t be my last! They had all the items I needed in one place and the
prices are the best I could find online.
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I used to buy my meds online but I had to pay a good amount
for shipping. When I found this site I was thrilled to see they offer free discreet
shipping. I am saving significantly more money.
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