HIVIsentress (Generic)
Generic drugs, marketed without brand names, contain the exact same active ingredients used in their brand-name counterparts, but cost significantly less. The drugs are required to meet US Food and Drug Administration (FDA) standards for safety, purity and effectiveness.
Isentress®
Isentress, also known as raltegravir, is an antiretroviral medication that stops the human immunodeficiency virus, often known as HIV, from replicating inside of a person's body. Isentress is a drug that is prescribed for the treatment of HIV, which is a virus that can lead to acquired immunodeficiency syndrome (AIDS). Raltegravir is not a treatment that can cure HIV or AIDS on its own.
Generic Isentress, known by its generic name Raltegravir, is an antiretroviral medication used to treat human immunodeficiency virus (HIV) infection. It belongs to the class of drugs known as integrase strand transfer inhibitors (INSTIs), which work by blocking the integration of HIV DNA into the host cell's DNA, a critical step in the HIV replication cycle. Raltegravir is often used in combination with other antiretroviral drugs as part of highly active antiretroviral therapy (HAART) to suppress viral load, improve immune function, and reduce the risk of HIV-related complications. Generic Isentress is widely prescribed due to its efficacy, affordability, and ability to provide a potent and well-tolerated treatment option for HIV patients.
Mechanism of Action
Raltegravir exerts its therapeutic effects through the following mechanisms:
Inhibition of HIV Integrase:
Raltegravir specifically targets the HIV integrase enzyme, which is responsible for integrating viral DNA into the host cell's DNA.
Blockade of Viral Replication:
By inhibiting integrase, Raltegravir prevents the integration of HIV DNA into the host genome, halting the production of new viral particles.
Reduction in Viral Load:
The inhibition of viral replication leads to a significant reduction in HIV viral load in the blood.
Immune System Recovery:
By suppressing viral replication, Raltegravir helps restore immune function and reduce the risk of opportunistic infections.
Indications and Uses
Generic Isentress is indicated for the following conditions:
HIV Infection:
Used in combination with other antiretroviral drugs to treat HIV-1 infection in adults and pediatric patients weighing at least 2 kg.
Suitable for both treatment-naïve patients and those who have previously received antiretroviral therapy.
Post-Exposure Prophylaxis (PEP):
May be used as part of a combination regimen to prevent HIV infection after potential exposure (e.g., needlestick injuries or unprotected sex).
Off-Label Uses:
Pre-Exposure Prophylaxis (PrEP): Investigated for use in preventing HIV infection in high-risk individuals, though not yet approved for this indication.
Dosage and Administration
The dosage of Generic Isentress varies depending on the patient's age, weight, and treatment history:
Adults and Adolescents (≥40 kg):
Standard Dose: 400 mg twice daily.
Once-Daily Dose: 1200 mg (two 600 mg tablets) once daily, approved for treatment-naïve or virologically suppressed patients switching from a twice-daily regimen.
Pediatric Patients (≥2 kg):
Dose is based on body weight and administered as chewable tablets or oral suspension.
Administration Guidelines:
Take with or without food.
Swallow the tablets whole or chew them thoroughly if using chewable tablets.
Shake the oral suspension well before use.
Pharmacokinetics
Absorption: Raltegravir is rapidly absorbed from the gastrointestinal tract, with peak plasma concentrations reached within 1-2 hours.
Distribution: It is widely distributed in body tissues, with moderate binding to plasma proteins.
Metabolism: Metabolized in the liver primarily by UGT1A1-mediated glucuronidation.
Excretion: Primarily excreted in the feces (as metabolites) and urine, with a half-life of approximately 9-12 hours.
Side Effects
While Generic Isentress is generally well-tolerated, some patients may experience side effects, including:
Common Side Effects:
Headache
Nausea or vomiting
Diarrhea
Fatigue
Less Common Side Effects:
Insomnia
Dizziness
Rash
Elevated liver enzymes
Serious Side Effects (rare):
Severe skin reactions (e.g., Stevens-Johnson syndrome)
Generic Isentress should be used with caution or avoided in certain situations:
Contraindications:
Hypersensitivity to Raltegravir or any component of the medication.
Precautions:
Pregnancy and Lactation: Use only if clearly needed, as the safety profile is not well-established.
Elderly Patients: Increased risk of side effects, such as kidney or liver dysfunction.
Liver Impairment: Monitor liver function regularly during treatment.
Drug Interactions: Raltegravir may interact with other medications, requiring dose adjustments or alternative therapies.
Drug Interactions
Raltegravir may interact with other medications, including:
Antacids or Calcium Supplements:
May reduce the absorption of Raltegravir; take Raltegravir 2 hours before or 6 hours after these medications.
Rifampin:
Reduces Raltegravir levels, requiring a dose increase to 800 mg twice daily.
Other Antiretroviral Drugs:
May be used in combination with other antiretrovirals, but requires careful monitoring for interactions.
UGT1A1 Inhibitors:
Drugs like atazanavir may increase Raltegravir levels, increasing the risk of side effects.
Advantages of Generic Isentress
Cost-Effectiveness:
Generic Isentress is more affordable than branded versions, making it accessible to a wider population.
Potent Antiretroviral Activity:
Clinically proven to effectively suppress viral load and improve immune function.
Well-Tolerated:
Generally causes fewer side effects compared to older antiretroviral drugs.
Flexible Dosing:
Available in twice-daily and once-daily formulations, providing flexibility for patients.
Limitations and Challenges
Resistance:
HIV can develop resistance to Raltegravir, particularly if the medication is not taken as prescribed.
Drug Interactions:
Requires careful management of interactions with other medications.
Not a Cure:
Raltegravir suppresses HIV but does not cure the infection.
Patient Counseling and Education
Patients prescribed Generic Isentress should be advised to:
Take the medication exactly as prescribed and at the same time each day.
Avoid missing doses to prevent the development of drug resistance.
Report any signs of severe side effects, such as rash, muscle pain, or difficulty breathing.
Inform their healthcare provider about all other medications they are taking to avoid potential interactions.
Conclusion
Generic Isentress (Raltegravir) is a highly effective and affordable antiretroviral medication for the treatment of HIV infection. Its ability to inhibit HIV integrase provides significant benefits for viral suppression and immune recovery. While it is generally well-tolerated, patients and healthcare providers must remain vigilant about potential side effects and drug interactions. With proper use and adherence, Generic Isentress can significantly improve outcomes and quality of life for patients living with HIV.
Raltegravir tablets
Raltegravir is an acronym for what?
The antiviral medication raltegravir stops the human immunodeficiency virus, also known as HIV, from replicating in your body.
As a treatment for HIV, the virus that can lead to acquired immunodeficiency syndrome (AIDS), raltegravir is utilized (AIDS). Raltegravir is not a treatment that can cure HIV or AIDS on its own.
Raltegravir should only be administered to patients who are at least 4.4 pounds in weight, including both adults and children (2 kilograms).
Moreover, this drug guide may not include all of the possible applications for raltegravir.
Warnings
If you experience any of the following symptoms while taking raltegravir: fever, joint or muscle pain, trouble breathing, stomach pain, vomiting, dark urine, yellowing of the skin or eyes, burning eyes, mouth sores, rash, blistering or peeling skin, or swelling in the face or throat, you should seek immediate medical attention.
Before beginning to use this medication
If you weigh less than 40 kilograms (88 pounds), you should not take the film-coated tablets of Isentress HD (40 kilograms).
Talk to your primary care physician about all of the medications you are currently taking, as well as any new ones or ones you discontinue taking. There are many medications that can interact with one another, and certain drugs should never be used together.
Tell your doctor if you have ever suffered from any of the following conditions: kidney disease (or if you are currently receiving dialysis); liver disease; mental illness or depression; high blood levels of an enzyme called creatine kinase (which is a sign of muscle damage); kidney disease; or high blood levels of an enzyme called creatine kinase.
Phenylalanine is included in the chewable tablet form of raltegravir. Inform your primary care provider if you suspect that you have phenylketonuria (PKU).
It is unknown at this time whether or not raltegravir will cause damage to an unborn child. When you are taking this medication, you should inform your doctor if you are pregnant or if you intend to become pregnant in the near future.
If the virus is not managed properly during pregnancy, it is possible for it to be passed on to the baby. If you are pregnant, there is a possibility that your name may be added to a register that monitors the effects of antiviral medication on the developing baby. Make sure you take all of your HIV medicine as directed.
When you are taking this medication, you should not breastfeed your child. It is not recommended that mothers who have HIV or AIDS breastfeed their children. It is possible for your infant to get HIV from you through breast milk even if they do not have the virus at birth.
How exactly am I supposed to take raltegravir?
Read all of the medication guides or instruction papers that come with your medicine, and make sure to follow all of the guidelines that are included on the prescription label. Always follow the directions on the label while taking medication.
Raltegravir can be taken with or without food depending on your preference.
You should always be sure to read and carefully follow any instructions that come with your medication. If you are unable to comprehend these directions, please see your physician or pharmacist.
If you move to a new brand, strength, or formulation of raltegravir, your dosage requirements may alter as a result. It is important to strictly adhere to your physician's instructions on the dosage type and strength of any medicine you take.
If your kid is on this medication, you should let their doctor know if they have any changes in their weight. Doses of raltegravir are determined for children based on their weight, so if your child's weight changes in any way, this might influence their dosage.
Take all of your HIV medicine exactly as prescribed, and make sure you read all of the instruction manuals that come with it. Do not adjust either your dose or your dosing regimen without first consulting your physician. Every individual living with HIV should continue to receive treatment from a medical professional.
Keep at room temperature and away from heat and moisture when storing. While not in use, ensure that the cap is securely fastened on the bottle.
Retain the chewable tablets in their original container and store them alongside the moisture-absorbing preservative either in a packet or a canister.
What should I try to steer clear of while I'm on raltegravir?
Inquire with your physician first before using an antacid, and be sure to stick to the brand that he or she advises. It's possible that using some antacids will make it more difficult for your body to absorb raltegravir.
It is possible that taking raltegravir will not stop the illness from spreading. Do not engage in unprotected sexual activity, nor should you share utensils such as razors or toothbrushes. Have a conversation with your healthcare provider about the best and safest strategies to stop the spread of HIV via sexual activity. It is never safe, even for a healthy individual, to share needles that have been used for drugs or medicine.
Raltegravir side effects
Stop taking this medication immediately and seek immediate medical attention if you experience any of the following symptoms of an allergic reaction: fever, a general feeling of illness, tiredness, joint or muscle pain, difficulty breathing; pain in the upper stomach; vomiting; loss of appetite; dark urine; yellowing of the skin or eyes; burning eyes; blisters or mouth sores; rash, hives; blistering or peeling skin; swelling of the face, lips, tongue, or throat.
In extremely unusual instances, using raltegravir can lead to a syndrome known as raltegravir-associated myopathy, which causes the destruction of skeletal muscle tissue and ultimately renal failure. If you have muscular discomfort, soreness, or weakness that cannot be explained, you should contact your doctor as soon as possible. This is especially important if you also have a fever, unusual weariness, or urine that is a dark color.
Since raltegravir has an influence on your immune system, it is possible that it will induce some adverse effects (even after several weeks or months have passed since you've stopped taking this medication). Talk to your primary care physician if you experience any of the following symptoms: fever, night sweats, swollen glands, cold sores, cough, wheezing, diarrhea, weight loss; difficulty speaking or swallowing; problems with balance or eye movement; weakness or a prickly feeling; or swelling in your neck or throat (enlarged thyroid); menstrual changes; or impotence.
The following are examples of common adverse effects that may occur: nausea, headache, dizziness, feeling weary, or having trouble sleeping (insomnia).
What other medications might potentially interact with raltegravir?
It is possible that using certain drugs at the same time might have adverse effects. Some medications have the potential to alter the blood levels of other medications that you take, which may result in an increase in adverse effects or a reduction in the efficacy of the prescriptions.
Talk to your primary care provider about any and all medications you're currently taking. There are a variety of medications that can interact with raltegravir, including: fenofibrate or gemfibrozil; rifampin; HIV or AIDS medication such as etravirine, ritonavir, tipranavir, zidovudine; seizure medication such as carbamazepine, phenobarbital, or phenytoin; or a "statin" cholesterol-lowering medication such as Crestor,
This list is not exhaustive, and the effects of raltegravir may also be influenced by a great number of other medications. This include both prescription and over-the-counter medications, in addition to herbal and vitamin supplements. This page does not provide a complete listing of all possible medication interactions.
Testimonials
What’s great about this site is they have such a wide
selection of products. I wasn’t happy with my current ED product was using, so I was able to
try out a different kind and see if it was a better fit for my needs. Which it was!
– John, Wellington
I have been buying brand meds name for years and it never
crossed my mind how much cheaper the generic versions were. When I started browsing the
items I couldn’t believe the price difference! This is my go to shop right now.
– Eric, London
I wasn’t quite sure about buying my medication online as I
always bought it in store. I spoke to one of their support reps and they were really nice
and helped to explain how it works and made me feel much more comfortable with my order!
– Jenna, Leeds
has all the best generic items at crazy good prices. I order here every month.
– Pete, Birmingham
I got my package in just under a week with no problems at all!
Highly recommended.
– Jerry, Quebec
It was my first time ordering at
and it definitely won’t be my last! They had all the items I needed in one place and the
prices are the best I could find online.
– Phil, Ontario
I used to buy my meds online but I had to pay a good amount
for shipping. When I found this site I was thrilled to see they offer free discreet
shipping. I am saving significantly more money.
– Arthur, Vancouver
You cannot compare the prices found at
to anywhere else online. These are the best prices by far!
– Barbara, Auckland
What’s great about this site is they have such a wide
selection of products. I wasn’t happy with my current ED product was using, so I was able to
try out a different kind and see if it was a better fit for my needs. Which it was!
– John, Wellington
I have been buying brand meds name for years and it never
crossed my mind how much cheaper the generic versions were. When I started browsing the
items I couldn’t believe the price difference! This is my go to shop right now.
– Eric, London
I wasn’t quite sure about buying my medication online as I
always bought it in store. I spoke to one of their support reps and they were really nice
and helped to explain how it works and made me feel much more comfortable with my order!
– Jenna, Leeds
has all the best generic items at crazy good prices. I order here every month.
– Pete, Birmingham
I got my package in just under a week with no problems at all!
Highly recommended.
– Jerry, Quebec
It was my first time ordering at
and it definitely won’t be my last! They had all the items I needed in one place and the
prices are the best I could find online.
– Phil, Ontario
I used to buy my meds online but I had to pay a good amount
for shipping. When I found this site I was thrilled to see they offer free discreet
shipping. I am saving significantly more money.
– Arthur, Vancouver
You cannot compare the prices found at
to anywhere else online. These are the best prices by far!
– Barbara, Auckland