Alzheimer's And Parkinson'sStalevo (Generic)
Generic drugs, marketed without brand names, contain the exact same active ingredients used in their brand-name counterparts, but cost significantly less. The drugs are required to meet US Food and Drug Administration (FDA) standards for safety, purity and effectiveness.
Stalevo
In the brain, L-DOPA undergoes a chemical transformation that results in the production of dopamine. Dopamine deficiency in the brain is one possible source of the symptoms associated with Parkinson's disease. CARBIDOPA works to stop the breakdown of levodopa before it reaches the brain and has an impact there. Levodopa levels in the body are raised as a result of entacapone use.
Carbidopa, entacapone, and levodopa are the three medications that are typically used in conjunction with one another to treat Parkinson's disease symptoms like rigidity in the muscles, tremors, and spasms in the muscles.
Generic Stalevo is a combination medication used primarily in the management of Parkinson's disease. It is a generic version of the brand-name drug Stalevo, which is manufactured by Novartis. The medication combines three active ingredients: Levodopa, Carbidopa, and Entacapone. Each of these components plays a crucial role in alleviating the symptoms of Parkinson's disease, a progressive neurological disorder characterized by tremors, rigidity, bradykinesia (slowness of movement), and postural instability. Generic Stalevo is widely prescribed due to its efficacy, cost-effectiveness, and ability to improve the quality of life for patients with Parkinson's disease.
Composition and Mechanism of Action
Levodopa: Levodopa is the cornerstone of Parkinson's disease treatment. It is a precursor to dopamine, a neurotransmitter that is deficient in the brains of Parkinson's patients. Levodopa crosses the blood-brain barrier and is converted into dopamine, replenishing the depleted levels and alleviating motor symptoms.
Carbidopa: Carbidopa is a peripheral decarboxylase inhibitor. It prevents the breakdown of Levodopa in the bloodstream before it reaches the brain. By inhibiting the enzyme dopa decarboxylase, Carbidopa ensures that more Levodopa is available for conversion to dopamine in the brain, thereby enhancing its efficacy and reducing peripheral side effects such as nausea and vomiting.
Entacapone: Entacapone is a catechol-O-methyltransferase (COMT) inhibitor. It works by blocking the COMT enzyme, which is responsible for breaking down Levodopa in the body. By inhibiting this enzyme, Entacapone prolongs the duration of Levodopa's action, providing more consistent symptom control and reducing the "wearing-off" effect that many patients experience as the disease progresses.
Indications
Generic Stalevo is indicated for the treatment of Parkinson's disease, particularly in patients who are experiencing motor fluctuations such as end-of-dose "wearing-off" phenomena. It is typically prescribed when Levodopa/Carbidopa therapy alone is no longer sufficient to control symptoms. The combination of Levodopa, Carbidopa, and Entacapone provides a more stable and prolonged therapeutic effect, making it a valuable option for patients with advanced Parkinson's disease.
Dosage and Administration
Generic Stalevo is available in various strengths, which are determined by the amount of Levodopa, Carbidopa, and Entacapone in each tablet. Common strengths include:
The dosage is individualized based on the patient's response to treatment, the severity of symptoms, and the presence of motor complications. It is usually taken orally, with or without food, and the frequency of administration is determined by the prescribing physician. Patients are advised to follow their healthcare provider's instructions carefully and not to adjust the dosage without consultation.
Pharmacokinetics
Absorption: Levodopa is rapidly absorbed from the gastrointestinal tract, but its absorption can be influenced by food, particularly high-protein meals. Carbidopa and Entacapone are also well-absorbed, with peak plasma concentrations occurring within 1-2 hours after ingestion.
Distribution: Levodopa crosses the blood-brain barrier, while Carbidopa and Entacapone primarily remain in the periphery. The combination ensures that Levodopa is efficiently converted to dopamine in the brain.
Metabolism: Levodopa is metabolized in both the periphery and the brain. Carbidopa inhibits peripheral metabolism, while Entacapone inhibits COMT-mediated metabolism, prolonging Levodopa's action.
Excretion: The metabolites of Levodopa, Carbidopa, and Entacapone are primarily excreted in the urine. Renal function can influence the clearance of these drugs, so dosage adjustments may be necessary in patients with impaired kidney function.
Side Effects
Like all medications, Generic Stalevo can cause side effects, which may vary in severity. Common side effects include:
Nausea and Vomiting: These are often related to the peripheral conversion of Levodopa to dopamine. Carbidopa helps mitigate these effects, but they may still occur, especially at the beginning of treatment.
Dyskinesias: Involuntary movements, such as twitching or jerking, can occur as a result of prolonged Levodopa therapy. These are more common in advanced stages of Parkinson's disease.
Orthostatic Hypotension: A drop in blood pressure upon standing can occur, leading to dizziness or fainting. Patients are advised to rise slowly from a sitting or lying position.
Discoloration of Urine and Sweat: Entacapone can cause a harmless discoloration of urine and sweat, turning them a reddish-brown color. This is not harmful but can be alarming if patients are not informed.
Gastrointestinal Disturbances: Diarrhea, constipation, and abdominal pain may occur, particularly with Entacapone.
Psychiatric Effects: Levodopa can cause or exacerbate psychiatric symptoms such as hallucinations, confusion, and sleep disturbances, especially in elderly patients or those with a history of psychiatric disorders.
Contraindications and Precautions
Generic Stalevo is contraindicated in patients with a known hypersensitivity to any of its components. It should also be avoided in patients with narrow-angle glaucoma, as Levodopa can increase intraocular pressure. Additionally, caution is advised in patients with a history of melanoma or other skin cancers, as Levodopa has been associated with an increased risk of melanoma.
Patients with severe cardiovascular, pulmonary, renal, hepatic, or endocrine diseases should be closely monitored while on Generic Stalevo. The medication should be used with caution in patients with a history of psychiatric disorders, as it can exacerbate symptoms.
Drug Interactions
Generic Stalevo can interact with several other medications, potentially altering its efficacy or increasing the risk of adverse effects. Notable drug interactions include:
MAO Inhibitors: Concurrent use of monoamine oxidase (MAO) inhibitors with Generic Stalevo can lead to hypertensive crises. MAO inhibitors should be discontinued at least two weeks before starting Generic Stalevo.
Antipsychotics: Dopamine receptor antagonists, such as typical and atypical antipsychotics, can counteract the effects of Levodopa, reducing its efficacy.
Iron Supplements: Iron can reduce the absorption of Levodopa, so it is recommended to take iron supplements at least 2-3 hours apart from Generic Stalevo.
Antihypertensives: Generic Stalevo can potentiate the effects of antihypertensive medications, leading to excessive hypotension.
COMT Inhibitors: Other COMT inhibitors should not be used concomitantly with Generic Stalevo, as this can increase the risk of adverse effects.
Special Populations
Elderly Patients: Elderly patients may be more susceptible to the side effects of Generic Stalevo, particularly psychiatric effects and orthostatic hypotension. Dosage adjustments may be necessary.
Pregnant and Lactating Women: The safety of Generic Stalevo in pregnancy and lactation has not been established. It should be used only if the potential benefits outweigh the risks.
Pediatric Patients: Generic Stalevo is not indicated for use in children, as Parkinson's disease is primarily a disorder of the elderly.
Renal and Hepatic Impairment: Patients with renal or hepatic impairment may require dosage adjustments, as the clearance of the drug may be reduced.
Clinical Efficacy
Numerous clinical trials have demonstrated the efficacy of Generic Stalevo in managing the symptoms of Parkinson's disease, particularly in patients experiencing motor fluctuations. The combination of Levodopa, Carbidopa, and Entacapone has been shown to provide more consistent symptom control compared to Levodopa/Carbidopa alone. Patients on Generic Stalevo often experience a reduction in "off" time (periods when medication is not working effectively) and an increase in "on" time (periods of good symptom control).
Cost-Effectiveness
As a generic medication, Generic Stalevo is generally more affordable than the brand-name version, making it a cost-effective option for patients and healthcare systems. The availability of generic versions has increased access to effective Parkinson's disease treatment, particularly in low- and middle-income countries.
Conclusion
Generic Stalevo is a valuable therapeutic option for patients with Parkinson's disease, particularly those experiencing motor fluctuations. By combining Levodopa, Carbidopa, and Entacapone, it provides more consistent symptom control and improves the quality of life for many patients. While it is generally well-tolerated, patients and healthcare providers must be aware of potential side effects, contraindications, and drug interactions. With proper use and monitoring, Generic Stalevo can be an effective and cost-efficient treatment for managing the complex symptoms of Parkinson's disease.
Carbidopa, entacapone, and levodopa pills
What kind of medication is this?
In the brain, L-DOPA undergoes a chemical transformation that results in the production of dopamine. Dopamine deficiency in the brain is one possible source of the symptoms associated with Parkinson's disease. CARBIDOPA works to stop the breakdown of levodopa before it reaches the brain and has an impact there. Levodopa levels in the body are raised as a result of entacapone use.
Carbidopa, entacapone, and levodopa are the three medications that are typically used in conjunction with one another to treat Parkinson's disease symptoms like rigidity in the muscles, tremors, and spasms in the muscles.
Before I start using this medication, what should I discuss with my primary care physician?
If you have used an MAO inhibitor in the past 14 days, such as furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), or tranylcypromine (Parnate), you should not take this drug.
If you have an allergy to carbidopa (Lodosyn), entacapone (Comtan), or levodopa (Larodopa), or if you have any of the following conditions, you should not use this medication:
narrow-angle glaucoma;
skin lesions that are not typical and have not been examined by a physician; or
a family history of aggressive forms of melanoma (skin cancer).
Tell your doctor if you have any of the following medical problems in order to determine whether or not you may take this medicine safely:
coronary artery disease, excessive blood pressure, heart disease, a cardiac rhythm abnormality, or a previous episode of a heart attack; heart disease
respiratory disorders such as asthma, chronic obstructive pulmonary disease (COPD), or another condition;
disease of the kidneys, illness of the liver, or blockage of the bile ducts;
a disorder of the endocrine (hormonal) system;
an ulcer in the digestive tract or stomach;
glaucoma; or
a depressive disorder or other form of mental disease.
When you are on this drug, you can experience heightened sexual impulses, unexpected cravings to gamble, or other powerful urges. These side effects are possible but not guaranteed. Speak to your healthcare provider if you feel as though you are experiencing any strange or strong desires while taking this medication.
Carbidopa, entacapone, and levodopa may produce hallucinations (the sensation of hearing or seeing something that is not there). If you are having hallucinations, you should contact your physician immediately.
Parkinson's disease treatment has been linked to an increased risk of skin cancer in some patients (melanoma). On the other hand, those who suffer from Parkinson's disease may have an increased likelihood of developing melanoma. Discuss this risk and the skin signs you should look out for with your primary care physician. You should probably get your skin checked on a regular basis.
FDA pregnancy category C. It is unknown if carbidopa, entacapone, or levodopa will cause damage to a developing infant if it is used during pregnancy. When you are taking this medicine, you should inform your doctor if you are pregnant or if you intend to become pregnant in the near future.
Carbidopa, entacapone, and levodopa have all been shown to enter breast milk, where they pose a risk to breastfeeding infants. While you are under the influence of carbidopa, entacapone, and levodopa, you should not breastfeed your child.
What is the correct way to take this medication?
Follow the instructions given by your doctor to the letter. Use exactly as directed, neither in bigger nor lesser doses, nor for a longer period of time than is advised. Always make sure to follow the instructions on the label of your medication. To maintain a consistent level of the drug in your body at all times, you should take your medication at predetermined intervals.
When you are taking this medicine, it is important that you consume a lot of fluids.
It might take a few weeks before you start to see an improvement in your symptoms. You should consult your doctor if, after a few weeks of treatment, your symptoms have not improved despite your continued use of the drug as advised. Inform your healthcare provider if you feel that the effects of this drug are wearing off too soon in between dosages.
Make an appointment with your primary care physician if you experience persistent nausea or diarrhea, or if you are sweating more than normal. While taking this drug, it is easy to get dehydrated, which can result in dangerously low blood pressure or an electrolyte imbalance. Both of these conditions can be life-threatening.
Carbidopa, entacapone, and levodopa should not be discontinued without first discussing this decision with your physician. It's possible that you may need to go back on your dosage gradually before you can stop taking the drug entirely.
Some medical tests may provide odd findings if taken while taking this medicine. Carbidopa, entacapone, and levodopa are all medications that you should inform any physician who treats you that you are taking.
What should I do if I forget a dose?
When you realize you missed a dosage, take it as soon as you can. If it is almost time for your next scheduled dosage, you should skip the dose that you missed. It is not necessary to take additional medication in order to make up for a missed dosage.
What side effects should I be on the lookout for while I'm taking this medication?
Carbidopa, entacapone, and levodopa have the potential to affect one's thinking as well as their emotions. While you are driving or engaging in any activity that needs you to be aware, exercise extreme caution. If you have been sitting or lying down, you should avoid getting up too quickly because you may have dizziness. In order to avoid falling, carefully stand up while keeping your balance.
Steer clear of protein-rich diets and iron supplements if you want to maintain a healthy weight (protein sources include meat, eggs, and cheese). Your body may have a more difficult time digesting and absorbing carbidopa, entacapone, and levodopa if you do any of these things.
What potential negative reactions may I have to this medication?
If you have any of the following symptoms of an allergic reaction, you should seek immediate medical attention: hives; trouble breathing; swelling of your face, lips, tongue, or neck.
If you have any of the following major adverse effects, you should contact your doctor as soon as possible:
Nausea, sweating, and the sensation that you could pass out are common side effects of this medicine, especially when it is initially used.
symptoms such as melancholy, disorientation, hallucinations, strange thoughts or behavior, and a preoccupation with self-harm include:
signs that are becoming worse, such as tremors, twitching, or movements that you can't control in your eyes, lips, tongue, face, arms, or legs;
severe or persistent diarrhea, intense thirst, a rise in the amount of urine passed, a loss of weight, soreness in the legs, a sense of muscular weakness or limpness, and an irregular heart rate;
experiencing extreme thirst or heat, being unable to pee, profuse perspiration, or having skin that is both hot and dry;
a heartbeat that is irregular, hammering, or rapid;
Pain or a heavy sensation in the chest, discomfort that spreads to the arm or shoulder, and an overall feeling of illness;
a sense of tightness in the chest, a cough that is either new or getting worse, fever, and difficulty breathing;
a tendency to bruise or bleed easily, feces that are bloody or sticky, and coughing up blood;
a painful sensation or a burning sensation as you urinate; or
muscular discomfort, soreness, or weakness that cannot be explained.
Among the less serious potential adverse effects are:
discomfort or disturbance in the stomach, loss of appetite, and constipation;
alterations to your perception of taste, as well as dry mouth;
unexpected skin changes. a relatively little rash or irritation;
symptoms such as sleepiness or dizziness, headache, and blurred vision;
soreness in the back or the muscles; or other symptoms
tension or worry, trouble sleeping (insomnia), and unusual dreaming are all symptoms.
It is possible for you to observe that your perspiration, urine, or saliva have a dark color, such as a reddish, brownish, or black hue. This side effect is not dangerous in and of itself, but it could potentially stain your clothing or bed sheets.
What other substances could react with this medication?
The drowsiness brought on by carbidopa, entacapone, and levodopa can be exacerbated by certain medications, including antihistamines, narcotic painkillers, sleeping pills, muscle relaxants, and medicines used to treat seizures, depression, and anxiety. Talk to your primary care provider if you take any of these other medications on a regular basis, or if you take any other medications for Parkinson's disease.
Inform your primary care physician about any and all additional medications you use, in particular:
apomorphine, also known as Apokyn;
cholestyramine (Prevalite, Questran);
dobutamine (Dobutrex);
epinephrine (found in products such as EpiPen and others);
isoniazid, which is used in the treatment of tuberculosis;
isoproterenol (Isuprel, Medihaler-Iso);
methyldopa (Aldomet);
metoclopramide (Reglan);
papaverine (Pavabid, Papacon, Pavagen, Pavacot);
phenytoin (Dilantin);
probenecid (Benemid);
medications to treat high blood pressure;
antibiotics such as ampicillin, chloramphenicol, erythromycin (also known as E.E.S., EryPed, Ery-Tab, Erythrocin, Pediazole, and others), or rifampin (also known as Rifadin, Rifater, and Rifamate);
an antidepressant such as amitriptyline (Elavil, Vanatrip, Limbitrol), doxepin (Sinequan), imipramine (Janimine, Tofranil), nortriptyline (Pamelor), and others; or a psychotherapy session.
psychiatric disorders can be treated with a variety of medications, including chlorpromazine (Thorazine), haloperidol (Haldol), prochlorperazine (Compazine), risperidone (Risperdal), and others.
This list is not exhaustive; additional medications may also have an effect on how carbidopa, entacapone, and levodopa work in the body. Discuss all of the drugs you use with your primary care provider. This covers items purchased with a prescription, those bought over the counter, vitamins, and herbal remedies. Do not begin taking a new medicine before consulting with your primary care physician.
Where exactly may I store my medication?
Keep at room temperature and away from heat and moisture when storing.
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What’s great about this site is they have such a wide
selection of products. I wasn’t happy with my current ED product was using, so I was able to
try out a different kind and see if it was a better fit for my needs. Which it was!
– John, Wellington
I have been buying brand meds name for years and it never
crossed my mind how much cheaper the generic versions were. When I started browsing the
items I couldn’t believe the price difference! This is my go to shop right now.
– Eric, London
I wasn’t quite sure about buying my medication online as I
always bought it in store. I spoke to one of their support reps and they were really nice
and helped to explain how it works and made me feel much more comfortable with my order!
– Jenna, Leeds
has all the best generic items at crazy good prices. I order here every month.
– Pete, Birmingham
I got my package in just under a week with no problems at all!
Highly recommended.
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It was my first time ordering at
and it definitely won’t be my last! They had all the items I needed in one place and the
prices are the best I could find online.
– Phil, Ontario
I used to buy my meds online but I had to pay a good amount
for shipping. When I found this site I was thrilled to see they offer free discreet
shipping. I am saving significantly more money.
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to anywhere else online. These are the best prices by far!
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