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Nilotinib capsules What is nilotinib? Nilotinib is a medication for cancer that inhibits the expansion and dissemination of cancer cells throughout the body. Nilotinib is prescribed to adults and children who are at least one year old for the treatment of Philadelphia chromosome positive chronic myeloid leukemia (CML). This kind of blood cancer can affect both adults and children. Nilotinib is often used only after other drugs have been tried without being successful in treating the condition. Moreover, this medication guide may not include all of the possible applications for nilotinib. Information That Is Vital You should not take nilotinib if you have long QT syndrome, low blood levels of potassium or magnesium, or if you have these conditions together. It is possible for nilotinib to trigger a life-threatening cardiac condition, particularly if you are also taking other medications at the same time. Talk to your primary care physician about any other medications you are taking. Before beginning therapy with nilotinib and periodically while you are receiving it, your heart function may need to be evaluated. If you experience rapid or pounding heartbeats in addition to acute dizziness, you should contact your doctor as soon as possible or receive emergency medical assistance (like you might pass out). You should not consume anything for at least two hours prior to taking nilotinib and for one hour after taking it. Before beginning to use this medication If you have an allergy to nilotinib or if you have any of the following conditions, you should not take it: low concentrations of potassium or magnesium in the blood; or a condition known as long QT syndrome, which affects the heart's rhythm. Please let your doctor know if you have ever been diagnosed with: cardiovascular illness, cardiac rhythm disorders, or long QT syndrome (in you or a member of your family); a stroke; You have issues with blood circulation in your legs; hemorrhage issues; low concentrations of potassium or magnesium in the blood; serious issues with lactose (the sugar found in milk); illness of the liver; pancreatitis, or either/or stomach removal by surgical procedure (total gastrectomy). Before beginning this therapy, it is recommended that you have a pregnancy test that comes back negative. Do not use nilotinib if you are pregnant. It is possible that the unborn child will be harmed. While you are taking nilotinib and for at least 14 days following your last dosage, you must use an effective method of birth control to prevent becoming pregnant. When you are taking nilotinib and for at least 14 days following your final dosage, you should refrain from breastfeeding your child. What is the correct way to take nilotinib? Nilotinib is typically administered once every twelve hours. Read all of the medication guides or instruction papers that come with your medicine, and make sure to follow all of the guidelines that are included on the prescription label. Always follow the directions on the label while taking medication. Nilotinib should be taken on an empty stomach, preferably at least one hour before a meal or at least two hours after a meal. Do not take this medication with eating. Consuming food might raise your blood levels of nilotinib, which in turn may enhance the severity of any negative side effects. Always remember to take your medication with a full glass of water. Take the pill as directed and completely. If you are unable to take a capsule in its entirety, you can open it and sprinkle the contents of the capsule into a spoonful of applesauce. Immediately and without chewing, ingest the concoction in its whole. Do not put it aside for use at a later time. You should not consume anything for at least two hours prior to taking nilotinib and for one hour after taking it. Nilotinib treatment should be continued indefinitely. Nilotinib treatment should be discontinued only on the advice of a qualified medical professional. Nilotinib may cause a decrease in the number of blood cells in your body. There will likely be frequent tests done on your blood. The timing of your cancer treatments might change depending on the results. Nilotinib may result in a dangerous condition affecting the heart. Before and throughout your therapy with nilotinib, an electrocardiograph, also known as an ECG (also referred to as an EKG), may be used to evaluate how well your heart is functioning. Keep at room temperature and away from heat and moisture when storing. What can I expect if I forget to take a dose? You should take the medication as soon as it is convenient for you to do so, but you should omit the missed dose if it is almost time for your next scheduled dosage. It is not recommended to take two dosages at once. Drowsiness and vomiting are two of the possible signs of an overdose. What should I try to steer clear of while I'm on nilotinib? Nilotinib and grapefruit have the potential to interact, which might result in undesirable side effects. Grapefruit products should be avoided at all costs. Nilotinib should not be used within 10 hours before or 2 hours after taking a medication that lowers stomach acid. Examples of such medications are Pepcid, Tagamet, and Zantac. You should not take an antacid that contains aluminum, magnesium, or simethicone (such as Di-Gel, Gaviscon, Maalox, Milk of Magnesia, Mylanta, or Rolaids) within two hours before or two hours after taking nilotinib. This includes taking an antacid that contains these ingredients within two hours of taking nilotinib. Nilotinib is capable of penetrating the body's fluids (urine, feces, vomit). While cleaning up a patient's bodily fluids, handling contaminated garbage or laundry, or changing a patient's diaper, caregivers should use rubber gloves to protect their hands. It is important to wash your hands both before and after removing the gloves. Separately launder dirty articles of clothes and linens from the rest of the laundry. Negative consequences of Nilotinib You should seek immediate medical attention if you have the following symptoms of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or neck. If you have signs of a significant cardiac condition, including rapid or pounding heartbeats as well as abrupt dizziness, you should contact your doctor as soon as possible or seek immediate medical assistance (like you might pass out). You should see your physician as soon as possible if you have: bleeding that is not normal (such as bruising, blood in your urine, or blood in your feces); inflammation, fast weight gain, and a sensation of being short of breath; a quick onset of headache, disorientation, impaired vision, and vertigo as a result of bleeding in the brain; Pain in the upper abdomen (which may radiate to the back), nausea or vomiting, dark urine, and jaundice (a yellowing of the skin or eyes) are all symptoms that may indicate a problem with either the liver or the pancreas. symptoms associated with low blood cell counts, including fever, chills, night sweats, mouth ulcers, pale complexion, and extreme weakness; symptoms of reduced blood flow, including discomfort in the legs or a sense of coldness, chest pain, numbness, difficulty walking, or speech difficulties; or Confusion, weakness, muscular cramps, nausea, vomiting, rapid or slow heart rate, reduced urine, and tingling in the hands, feet, or around the mouth are some of the symptoms that might be associated with the breakdown of tumor cells. Nilotinib may have an impact on the rate of growth in children. When your kid is on nilotinib, you should let their physician know if they are not growing at a typical pace. The following are examples of common adverse effects: gastrointestinal issues including sickness, diarrhoea, and constipation; a rash and a temporary loss of hair; night sweats; ache or discomfort in your muscles, joints, bones, or other connective tissues; a headache, a sensation of exhaustion, or a stuffy or runny nose, sneezing, coughing, and a sore throat are symptoms of a cold.