HypertensionVaseretic (Generic)
Generic drugs, marketed without brand names, contain the exact same active ingredients used in their brand-name counterparts, but cost significantly less. The drugs are required to meet US Food and Drug Administration (FDA) standards for safety, purity and effectiveness.
Vaseretic
The generic version of the drug Vaseretic is taken to treat high blood pressure. It achieves its effect by ridding the body of extra fluid and assisting in the relaxation of blood vessels.
Generic Vaseretic is a combination medication used primarily to treat high blood pressure (hypertension). It combines two active ingredients: enalapril maleate, an angiotensin-converting enzyme (ACE) inhibitor, and hydrochlorothiazide, a thiazide diuretic. This combination works synergistically to lower blood pressure by addressing different mechanisms involved in hypertension. Generic Vaseretic is the non-branded version of the medication, offering a cost-effective alternative to the branded product while maintaining the same therapeutic efficacy.
Composition and Mechanism of Action
Enalapril Maleate:
Class: ACE inhibitor
Mechanism: Enalapril works by inhibiting the ACE, which is responsible for converting angiotensin I to angiotensin II. Angiotensin II is a potent vasoconstrictor that also stimulates the release of aldosterone, leading to sodium and water retention. By inhibiting this enzyme, enalapril reduces vasoconstriction and decreases blood volume, thereby lowering blood pressure.
Effects: Vasodilation, reduced aldosterone secretion, and decreased peripheral resistance.
Hydrochlorothiazide:
Class: Thiazide diuretic
Mechanism: Hydrochlorothiazide works by inhibiting the sodium-chloride symporter in the distal convoluted tubule of the kidney. This action promotes the excretion of sodium and water, reducing blood volume and subsequently lowering blood pressure.
Effects: Diuresis, reduction in blood volume, and mild vasodilation.
Indications
Generic Vaseretic is indicated for the management of hypertension in patients who require combination therapy. It is particularly useful in patients who have not achieved adequate blood pressure control with monotherapy. The combination of an ACE inhibitor and a thiazide diuretic provides a more comprehensive approach to blood pressure management by targeting multiple pathways involved in hypertension.
Dosage and Administration
Dosage Forms: Generic Vaseretic is available in tablet form, typically combining enalapril maleate (10 mg) and hydrochlorothiazide (25 mg).
Dosage: The usual starting dose is one tablet taken once daily. The dosage may be adjusted based on the patient's response and tolerance. It is important to follow the prescribing physician's instructions and not to exceed the recommended dose.
Administration: The tablet should be taken orally, with or without food. It is generally recommended to take it at the same time each day to maintain consistent blood levels of the medication.
Pharmacokinetics
Enalapril Maleate:
Absorption: Well absorbed from the gastrointestinal tract, with peak plasma concentrations occurring within 1 hour.
Metabolism: Converted to its active form, enalaprilat, in the liver.
Excretion: Primarily excreted by the kidneys.
Hydrochlorothiazide:
Absorption: Rapidly absorbed from the gastrointestinal tract, with peak plasma concentrations occurring within 2-4 hours.
Metabolism: Minimal metabolism in the liver.
Excretion: Primarily excreted by the kidneys.
Contraindications
Generic Vaseretic is contraindicated in patients with:
Known hypersensitivity to enalapril, hydrochlorothiazide, or any other sulfonamide-derived drugs.
History of angioedema related to previous ACE inhibitor therapy.
Anuria (absence of urine production).
Severe renal impairment.
Pregnancy, especially in the second and third trimesters, due to the risk of fetal harm.
Warnings and Precautions
Renal Impairment: Use with caution in patients with renal impairment. Regular monitoring of renal function is recommended.
Electrolyte Imbalance: Hydrochlorothiazide can cause electrolyte imbalances, including hypokalemia, hyponatremia, and hypomagnesemia. Regular monitoring of electrolytes is necessary.
Hyperglycemia: Thiazide diuretics may increase blood glucose levels, necessitating monitoring in diabetic patients.
Hypotension: Risk of hypotension, especially in volume-depleted patients. Careful dose titration is required.
Cough: ACE inhibitors can cause a persistent dry cough, which may require discontinuation of the medication.
Common adverse effects of Generic Vaseretic include:
Dizziness
Headache
Fatigue
Cough
Nausea
Diarrhea
Orthostatic hypotension
Hyperkalemia (with enalapril)
Hypokalemia (with hydrochlorothiazide)
Less common but serious adverse effects include:
Angioedema
Acute renal failure
Severe hypotension
Electrolyte imbalances
Pancreatitis
Hepatic dysfunction
Drug Interactions
Generic Vaseretic may interact with several other medications, including:
Potassium-sparing diuretics or potassium supplements: Increased risk of hyperkalemia.
Nonsteroidal anti-inflammatory drugs (NSAIDs): Reduced antihypertensive effect and increased risk of renal impairment.
Lithium: Increased lithium levels and toxicity.
Other antihypertensive agents: Additive hypotensive effects.
Diabetic medications: Thiazides may increase blood glucose levels, necessitating adjustments in diabetic therapy.
Special Populations
Pregnancy: ACE inhibitors are contraindicated during pregnancy due to the risk of fetal harm, including renal failure, oligohydramnios, and fetal death.
Lactation: Enalapril and hydrochlorothiazide are excreted in breast milk. The benefits and risks should be considered before using this medication in nursing mothers.
Elderly: Elderly patients may be more sensitive to the effects of the medication, particularly hypotension and renal impairment. Dose adjustments may be necessary.
Pediatric: Safety and efficacy in pediatric patients have not been established.
Overdose
Symptoms of overdose may include severe hypotension, electrolyte imbalances, and renal failure. Treatment is supportive and includes measures to correct hypotension and electrolyte abnormalities. Hemodialysis may be effective in removing enalaprilat and hydrochlorothiazide from the bloodstream.
Conclusion
Generic Vaseretic is an effective combination medication for the management of hypertension, offering the benefits of both an ACE inhibitor and a thiazide diuretic. Its dual mechanism of action provides a comprehensive approach to blood pressure control, making it a valuable option for patients who require combination therapy. However, like all medications, it must be used with caution, considering potential contraindications, adverse effects, and drug interactions. Regular monitoring and adherence to prescribed dosages are essential to ensure safe and effective treatment. As with any medication, patients should consult their healthcare provider for personalized medical advice and treatment plans.
Tablet containing Enalapril and Hydrochlorothiazide
What kind of medication is this?
It is a combination of a diuretic and an ACE inhibitor that goes by the name ENALAPRIL; HYDROCHLOROTHIAZIDE. It is a medication that is used to treat hypertension.
Before I start using this medication, what should I discuss with my primary care physician?
People have a right to know if you suffer from any of the following conditions:
illness affecting the bone marrow
reduced urine
illness of the heart or blood vessels
if you are following a particular diet, such as a diet low in salt, you should not eat this.
immune system disorder, like lupus
renal disease
illness of the liver
a lowering in the blood pressure
a history of enlargement of the tongue, face, or lips, accompanied by difficulties breathing or swallowing, hoarseness, or constriction of the throat
recent cardiac arrest or cerebrovascular accident
a reaction that is not typical or an allergic reaction to enalapril, hydrochlorothiazide, sulfa medications, other medicines, insect venom, foods, colors, or preservatives.
pregnant or attempting to get pregnant
breast-feeding
What is the correct way to take this medication?
This medication should be taken orally with a full glass of water. Always make sure to follow the instructions on the label of your medicine. You can take this medication either with or without food. Either way is OK. Always remember to space out your dosages evenly. Do not take your medication more frequently than recommended by the label. You should not stop taking this medication unless specifically instructed to do so by your physician or another qualified medical expert.
Have a discussion with your child's physician about the possibility of giving them this medication. It's possible that further attention is required.
In the event that you believe you may have taken an excessive amount of this medication, you should immediately contact a poison control center or an emergency facility.
PLEASE TAKE NOTE That no one else should use this medication. It is important that others not use this medication.
What should I do if I forget a dose?
If you forget to take a dosage, you should take it as soon as you remember it. Take only that dose if it is getting close to the time for your next scheduled dose. Do not take the recommended dose in double or excess amounts.
What other substances could react with this medication?
It is not safe to use this drug with any of the medicines listed below:
diazoxide
There is a possibility that this treatment will interact negatively with the following medications:
barbiturates similar phenobarbital
medications for high blood pressure
corticosteroids like prednisone
prescription drugs for diabetics
diuretics, notably triamterene, spironolactone or amiloride
lithium
Medications like cholestyramine and colestipol are used to treat high cholesterol.
NSAIDs, which include painkillers and anti-inflammatory medications such as ibuprofen and naproxen
potassium supplements
Medications available only by prescription
skeletal muscle relaxants like tubocurarine
It's probable that this list doesn't cover all of the possible interactions. Provide your primary care physician with a list of all the medications, herbs, over-the-counter pharmaceuticals, and dietary supplements that you are currently using. Additionally let them know whether you are a smoker, a drinker, or if you take any illicit substances. It's possible that certain things might react badly with your medication.
What side effects should I be on the lookout for when using this medication?
You should schedule frequent checkups with your primary care physician or another qualified medical expert. Do the necessary checks on your blood pressure. Consult your primary care physician or another qualified medical practitioner about the ideal range for your blood pressure and when you should follow up with him or her. If you experience an irregular or rapid heartbeat, you should contact your physician or another qualified medical expert immediately.
You must not get dehydrated. In order to determine how much liquids you should consume on a daily basis, consult your physician or another qualified medical practitioner. If you experience an episode of severe diarrhea, nausea and vomiting, or if you sweat a lot, you should get in touch with him or her as soon as possible. Using this medication while you have lost an excessive amount of bodily fluid may put your health at jeopardy.
If a woman has the desire to conceive or suspects that she may already be pregnant, she should consult her primary care physician. There is a possibility that an unborn kid will have major adverse consequences. Please see a member of your health care team or your pharmacist for further information.
You may become tired or dizzy. Do not get behind the wheel of a vehicle, operate heavy machinery, or engage in any activity that requires mental alertness until you have determined how this medicine affects you. Take it easy when getting up, especially if you are an older patient who needs medical attention. This lowers the likelihood of experiencing periods of lightheadedness or fainting. Drinking alcohol can amplify both drowsiness and lightheadedness. Steer clear of alcoholic beverages.
It is possible that this medication will change the amount of sugar in your blood. If you have diabetes, you should discuss any changes to the dosage of your diabetes medication with your primary care physician or another qualified medical expert.
If your doctor or another qualified medical practitioner advises you otherwise, you should steer clear of salt replacements.
This medication has the potential to increase your sensitivity to the sun. Stay out of the direct sunlight. Wear protective gear and be sure to apply sunscreen if you can't help but be outside in the sun. Avoid using sun lamps as well as tanning beds and booths.
While you are taking this medication, you should not self-medicate for coughs, colds, or discomfort without first consulting your physician or another qualified medical expert for guidance. There is a possibility that some of the substances will raise your blood pressure.
What potential adverse reactions may there be from using this medication?
You should report the following side effects to your physician or another qualified medical expert as soon as possible:
Allergic responses include rashes, itching, and hives on the skin, as well as swelling of the face, lips, and tongue.
issues with one's respiration
chest pain
lower volume of urine that was passed.
hacking cough
falling down when experiencing dizziness or fainting
muscular spasms
stomach upset and puking
a rash that may include redness, blistering, peeling, or loosening of the skin, even inside the mouth.
stomach discomfort
bruising or bleeding that is not normal, as well as tiny red areas on the skin
increased suffering from gout
symptoms including yellowing of the eyes and skin
Adverse effects that, in most cases, do not require immediate medical treatment include the following; nonetheless, you should inform your physician or another health care provider if they persist or become bothersome:
a shift in sexual motivation or performance
cough
headache
It's conceivable that this list doesn't cover all of the potential negative consequences.
Where should I store my medication, if you please?
Be sure that youngsters can't get their hands on it.
Keep at a temperature below 30 degrees Celsius, which is room temperature (86 degrees F). Maintain a secure lid on the container. Keep out any moisture that you can. After the expiration date, any medicine that has been used but not finished should be thrown away.
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try out a different kind and see if it was a better fit for my needs. Which it was!
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crossed my mind how much cheaper the generic versions were. When I started browsing the
items I couldn’t believe the price difference! This is my go to shop right now.
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always bought it in store. I spoke to one of their support reps and they were really nice
and helped to explain how it works and made me feel much more comfortable with my order!
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and it definitely won’t be my last! They had all the items I needed in one place and the
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