Xarelto
Cardiovascular Diseases, Surgery
Xarelto (Generic)
Generic drugs, marketed without brand names, contain the exact same active ingredients used in their brand-name counterparts, but cost significantly less. The drugs are required to meet US Food and Drug Administration (FDA) standards for safety, purity and effectiveness.
Xarelto
Generic Xarelto is an anticoagulant, sometimes known as a blood thinner, that was developed to reduce or eliminate the risk of blood clots. Deep vein thrombosis, often known as DVT, is a condition that can lead to the production of blood clots in the lungs. Xarelto is prescribed to patients to help reduce their risk of developing DVT (pulmonary embolism). After having certain surgical procedures done, you run the risk of developing a DVT. Patients who have been diagnosed with a cardiac rhythm issue, often known as atrial fibrillation, may benefit from treatment with Xarelto by reducing their likelihood of experiencing a stroke brought on by a clot in the bloodstream.
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Tablets containing rivaroxaban
What kind of medication is this?
RIVAROXABAN is a kind of anticoagulant, often known as a blood thinner, that works to prevent the clotting of blood.
Deep vein thrombosis, often known as DVT, is a form of blood clot that, if left untreated, can result in blood clots in the lungs. Xarelto is a medication that is used either to prevent or treat DVT (pulmonary embolism). Following some procedures, a patient is at risk for developing a DVT.
Those who have atrial fibrillation, which is a disturbance of the heart's rhythm, can also take Xarelto to lessen their risk of having a stroke brought on by a blood clot.
In addition to the applications described in this medication guide, Xarelto may also be used for other purposes.
Information that is essential to know
You should not use Xarelto if you have an artificial heart valve or if you have active or uncontrolled bleeding. Xarelto should also be avoided if you are pregnant or breastfeeding.
If you have a genetic spinal defect, if you have a spinal catheter in place, if you have a history of spinal surgery or repeated spinal taps, or if you are also using other drugs that can affect blood clotting, undergoing a spinal tap or receiving spinal anesthesia (epidural) while taking Xarelto can cause a very serious blood clot around your spinal cord. This is especially true if you are also taking other medications that can affect blood clotting. This particular blood clot can result in paralysis that is either temporary or permanent.
If you are experiencing back discomfort, tingling or muscular weakness in your lower body, loss of bladder or bowel control, or any other symptoms consistent with a spinal cord blood clot, you should seek immediate medical attention.
You should not stop taking Xarelto until seeing your healthcare provider first. Putting an abrupt end to your activity might raise your chance of having a blood clot or a stroke.
Before beginning to use this medication
If you have an allergy to rivaroxaban or any of the following conditions, you should not take Xarelto:
a mechanical replacement for the heart's valves; or
a bleeding that is vigorous or out of control.
If you get a spinal tap or are given spinal anesthesia while taking Xarelto, you run the risk of developing a life-threatening blood clot around your spinal cord (epidural). This particular form of blood clot has the potential to cause permanent paralysis and is more likely to occur if you have any of the following conditions:
You suffer from a congenital spinal malformation;
a spinal catheter has been inserted into your spine;
you have a previous medical history that includes spinal surgery or many spinal taps;
a spinal tap or epidural anesthesia was performed on you not too long ago;
if are using a non-steroidal anti-inflammatory drug (NSAID) such as Advil, Aleve, or Motrin; or
You are now taking additional medications for the treatment or prevention of blood clots.
Xarelto may make you more prone to bleeding, particularly if you have any of the following conditions:
a condition of blood clotting that can be hereditary or be the result of sickness;
a stroke caused by bleeding;
high blood pressure that is not under control;
ulcers or bleeding in the stomach or the intestines; or
if you regularly use certain medications, such as aspirin, heparin, warfarin (Coumadin, Jantoven), or clopidogrel, you may be at increased risk for bleeding (Plavix).
If you have renal illness or liver disease, you should discuss this with your doctor before beginning treatment with Xarelto.
pregnancy category C according to the FDA. It is unknown whether or not Xarelto will cause birth defects in an unborn child. On the other hand, this medication may increase the risk of bleeding difficulties during delivery. When you are taking this medicine, you should inform your doctor if you are pregnant or if you intend to become pregnant in the near future.
Please also see:
Warnings for expectant mothers and nursing mothers
It is unknown whether rivaroxaban is excreted into breast milk or whether it might cause problems for a breastfeeding infant. When you are using Xarelto, you should avoid breastfeeding your child.
What is the correct way to take rivaroxaban?
Always follow your physician's instructions when using Xarelto. Depending on the underlying condition being treated with Xarelto, the recommended dosage ranges from one tablet once day to two tablets twice daily. Always make sure to follow all of the instructions on the label of your medication. In order to optimize your treatment and provide the best possible outcomes, your physician may adjust your dosage on occasion. Do not use this medication in greater or lower doses than indicated, nor for a longer period of time than specified.
To treat atrial fibrillation, take one of the following dosages of Xarelto with your evening meal: 15 milligrams or 20 milligrams.
You can take the Xarelto 10-milligram tablet with or without food in order to prevent excessive bleeding after knee or hip replacement surgery.
If you find that a Xarelto tablet is difficult to swallow, be sure to let your healthcare provider know.
Be sure that any physician who treats you is aware that you are taking Xarelto. In the event that you require dental or surgical procedures, it is imperative that you inform your dentist or surgeon in advance that you are taking this prescription. It is possible that you will be required to discontinue the use of this medication for a period of time if you are about to undergo a medical treatment or operation that requires anesthesia.
Always follow your doctor's instructions when using Xarelto. It is important that you have the prescription for your medicine renewed before you run out completely.
It is imperative that you see your physician before making any adjustments to the dosage or discontinuing use of this medicine. Putting an abrupt end to your activity might raise your chance of having a blood clot or a stroke.
Keep at room temperature and away from heat and moisture when storing.
What can I expect if I forget to take a dose?
If you take Xarelto once per day, you should take the missing dosage as soon as you recall it if you take it once per day. Continue with your once-daily dosing regimen and take the next dose the day after you finish the previous one. It is not necessary to take additional medication in order to make up for a missed dosage.
If you normally take Xarelto twice daily, you should provide the missing dosage as soon as you realize it. If you need to make up for a dosage that you missed, you can take both of your regular doses at the same time.
What happens if I overdose?
Immediately seek out the assistance of a qualified medical professional or dial the Poison Help line at 1-800-222-1222.
An overdose might result in an excessive amount of bleeding.
What should I keep away from?
Steer clear of any actions that can raise your chances of getting cut or bleeding out. While shaving or cleaning your teeth, take additional precautions to avoid cutting yourself and bleeding.
Xarelto side effects
If you notice any of the following symptoms of an allergic response to Xarelto, you should seek immediate medical attention: hives; difficulty breathing; swelling of your face, lips, tongue, or neck.
If you are experiencing back discomfort, numbness or muscular weakness in your lower body, or loss of bladder or bowel control, you should also seek emergency medical assistance as soon as possible.
You should see your physician as soon as possible if you have:
easy bruising or bleeding (nosebleeds, bleeding gums, severe monthly flow);
discomfort, swelling, or discharge coming from a wound or the area of your skin where a needle was inserted;
hemorrhage caused by cuts or needle injections, as well as any bleeding that does not cease;
a headache, vertigo, a sense of weakness, and the sensation that you could pass out;
urine with a reddish, pinkish, or brownish color; or
diarrhea that is bloody or tarry, vomiting blood or vomit that looks like coffee grounds, and coughing up blood.
Common adverse reactions to Xarelto may include the following:
muscular ache;
irritation; or
ache or discomfort in your arms or legs.
This list of potential adverse effects is not exhaustive; additional symptoms may also surface. Make an appointment with your primary care physician to discuss any adverse effects. You can call the FDA at 1-800-FDA-1088 to report any adverse effects.
Information regarding the dosage of Xarelto
The following is the recommended adult dosage of Xarelto for the prevention of deep vein thrombosis following hip replacement surgery:
Patients who are going to have hip or knee replacement surgery should take the following precautions to prevent venous thromboembolism:
10 milligrams to be taken orally once daily, beginning six to ten hours after surgery.
The recovery time after knee replacement surgery is 12 days, while the recovery time after hip replacement surgery is 35 days.
After knee replacement surgery, the typical adult dose for the prevention of deep vein thrombosis is as follows:
Patients who are going to have hip or knee replacement surgery should take the following precautions to prevent venous thromboembolism:
10 milligrams to be taken orally once daily, beginning six to ten hours after surgery.
The recovery time after knee replacement surgery is 12 days, while the recovery time after hip replacement surgery is 35 days.
Standard Dose for Adults Diagnosed with Atrial Fibrillation:
Atrial Fibrillation That Is Not Caused by Valves
20 milligrams to be taken orally once daily with the supper meal.
The following is the typical adult dosage of Xarelto for the treatment of deep vein thrombosis:
The treatment for DVT and PE is as follows:
The recommended starting dose is 15 milligrams to be taken orally twice daily with food for the first 21 days.
For the remainder of treatment, the maintenance dose is 20 milligrams to be taken orally once daily with food.
Standard Dose for Adults in the Treatment of Pulmonary Embolism:
The treatment for DVT and PE is as follows:
The recommended starting dose is 15 milligrams to be taken orally twice daily with food for the first 21 days.
For the remainder of treatment, the maintenance dose is 20 milligrams to be taken orally once daily with food.
Standard Dose for Adults in the Treatment of Deep Vein Thrombosis � Ongoing Event:
Reduced Incidence of Deep Vein Thrombosis and Pulmonary Embolism
20 milligrams to be taken orally once a day with food.
Standard Dose of Xarelto Administered to Adults for the Treatment of Pulmonary Embolism � Ongoing Event:
Reduced Incidence of Deep Vein Thrombosis and Pulmonary Embolism
20 milligrams to be taken orally once a day with food.
What other medications might have an effect on Xarelto?
Tell your doctor about any and all medications you are currently taking, as well as any you start or stop taking while you are receiving treatment with Xarelto, particularly:
rifampin;
herb called St. John's wort;
antifungal medication�itraconazole or ketoconazole;
Medications for HIV, including indinavir, lopinavir, and ritonavir; or
seizure medication�carbamazepine, phenobarbital, phenytoin.
This list does not contain everything. There is a possibility that Xarelto could interact negatively with a number of other medications, including prescription and over-the-counter drugs, vitamins, and herbal products. This drug guide does not provide a description of all potentially harmful interactions.
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