Skin CareSoriatane (Generic)
Generic drugs, marketed without brand names, contain the exact same active ingredients used in their brand-name counterparts, but cost significantly less. The drugs are required to meet US Food and Drug Administration (FDA) standards for safety, purity and effectiveness.
Soriatane
Retinoid, which is another name for vitamin A, is what soriatane is. Adults with severe psoriasis can benefit from treatment with soriatane. It is possible that your psoriasis will return after you stop using this medication because it is not a treatment for the condition.
Generic Soriatane (Acitretin): A Comprehensive Overview
Introduction
Generic Soriatane, known by its generic name Acitretin, is a systemic retinoid medication primarily used in the treatment of severe skin conditions, particularly psoriasis. It is a second-generation retinoid, derived from vitamin A, and is known for its efficacy in managing dermatological disorders that are resistant to other forms of treatment. This article delves into the various aspects of Generic Soriatane, including its mechanism of action, indications, dosage, side effects, contraindications, and important considerations for patients and healthcare providers.
Mechanism of Action
Acitretin, the active ingredient in Generic Soriatane, works by modulating the growth and differentiation of skin cells. It binds to retinoic acid receptors (RARs) in the nucleus of cells, influencing gene expression and thereby regulating cell proliferation and differentiation. In psoriasis, a condition characterized by the rapid turnover of skin cells leading to the formation of thick, scaly plaques, Acitretin helps to normalize the growth cycle of skin cells, reducing the thickness and scaling of psoriatic lesions.
Indications
Generic Soriatane is indicated for the treatment of severe forms of psoriasis, including:
Plaque Psoriasis: The most common form of psoriasis, characterized by raised, red patches covered with a silvery white buildup of dead skin cells.
Pustular Psoriasis: A rare form of psoriasis characterized by white pustules (blisters of noninfectious pus) surrounded by red skin.
Erythrodermic Psoriasis: A severe and potentially life-threatening form of psoriasis that leads to widespread redness and scaling of the skin.
In addition to psoriasis, Acitretin may also be used off-label for other dermatological conditions such as:
Darier's Disease: A genetic skin disorder characterized by dark, crusty patches on the skin.
Lichen Planus: An inflammatory condition that can affect the skin, mouth, nails, and scalp.
Cutaneous T-cell Lymphoma: A type of non-Hodgkin lymphoma that primarily affects the skin.
Dosage and Administration
The dosage of Generic Soriatane is individualized based on the patient's weight, the severity of the condition, and their response to treatment. The typical starting dose for adults is 25 mg to 50 mg taken once daily with a meal, as food enhances the absorption of the medication. The dose may be adjusted by the healthcare provider based on the patient's tolerance and the clinical response.
It is important to follow the prescribed dosage and not to exceed the recommended amount, as higher doses increase the risk of side effects. Treatment with Acitretin is usually continued until the skin lesions have cleared or improved significantly, after which the dose may be tapered or the medication discontinued.
Side Effects
Like all medications, Generic Soriatane can cause side effects, which may vary in severity. Common side effects include:
Dry Skin and Mucous Membranes: Acitretin can cause dryness of the skin, lips, and eyes. Patients may experience chapped lips, dry mouth, and dry eyes, which can be managed with moisturizers and artificial tears.
Hair Loss: Some patients may experience thinning of the hair or hair loss, which is usually reversible upon discontinuation of the medication.
Nail Changes: Brittle nails or changes in nail texture may occur.
Elevated Liver Enzymes: Acitretin can affect liver function, leading to elevated liver enzymes. Regular monitoring of liver function tests is required during treatment.
Hyperlipidemia: Acitretin may increase levels of cholesterol and triglycerides in the blood. Lipid levels should be monitored, and dietary modifications or lipid-lowering medications may be necessary.
Less common but more serious side effects include:
Teratogenicity: Acitretin is highly teratogenic, meaning it can cause severe birth defects if taken during pregnancy. It is contraindicated in women who are pregnant or planning to become pregnant. Women of childbearing potential must use effective contraception during treatment and for at least 3 years after discontinuation of Acitretin.
Hepatotoxicity: In rare cases, Acitretin can cause severe liver damage. Symptoms of liver toxicity include jaundice, dark urine, and abdominal pain. Immediate medical attention is required if these symptoms occur.
Pseudotumor Cerebri: A condition characterized by increased pressure within the skull, leading to symptoms such as headache, nausea, vomiting, and visual disturbances. This is a rare but serious side effect that requires prompt medical intervention.
Contraindications
Generic Soriatane is contraindicated in the following situations:
Pregnancy: Acitretin is strictly contraindicated in pregnant women due to the high risk of severe birth defects.
Breastfeeding: Acitretin is excreted in breast milk and should not be used by nursing mothers.
Severe Liver or Kidney Impairment: Patients with severe liver or kidney disease should not use Acitretin, as it may exacerbate these conditions.
Hypersensitivity: Patients with a known hypersensitivity to Acitretin or other retinoids should avoid this medication.
Important Considerations
Pregnancy Prevention: Women of childbearing potential must use two forms of effective contraception for at least one month before starting Acitretin, during treatment, and for at least 3 years after stopping the medication. Regular pregnancy tests are required before, during, and after treatment.
Alcohol Consumption: Alcohol should be avoided during treatment with Acitretin, as it can increase the risk of liver toxicity and may also convert Acitretin to Etretinate, a retinoid with a much longer half-life.
Monitoring: Regular monitoring of liver function tests, lipid levels, and blood cell counts is essential during treatment with Acitretin. Patients should also be monitored for signs of depression or mood changes, as retinoids have been associated with psychiatric side effects.
Sun Exposure: Acitretin can make the skin more sensitive to sunlight. Patients should be advised to use sunscreen and protective clothing to minimize the risk of sunburn.
Drug Interactions: Acitretin may interact with other medications, including methotrexate, tetracyclines, and vitamin A supplements. Patients should inform their healthcare provider of all medications they are taking to avoid potential interactions.
Conclusion
Generic Soriatane (Acitretin) is a potent systemic retinoid that offers significant benefits in the management of severe psoriasis and other dermatological conditions. However, its use requires careful consideration of the potential risks, particularly teratogenicity and hepatotoxicity. Patients must be closely monitored, and adherence to safety guidelines is crucial to minimize adverse effects. With proper use and monitoring, Generic Soriatane can be an effective treatment option for patients with challenging skin conditions, improving their quality of life and overall skin health.
Tablets of acitretic acid
What precisely is the acitretin?
Acitretin is a retinoid, which is a type of vitamin A. Retinoids are found in the body naturally.
Acitretin is a medication that is prescribed to persons who suffer from severe psoriasis. Acitretin is not a cure for psoriasis, and if you stop taking this drug, you run the risk of experiencing a flare-up of your condition.
There are more applications for acitretine that are not included in this patient information leaflet.
Warnings
Acitretin has been linked to a number of serious birth abnormalities. Acitretin should not be used during pregnancy or if there is a possibility that you might get pregnant during the next three years after you stop taking acitretin.
When using acitretin and for at least three years following your last dose, you are need to utilize an effective method of birth control in order to avoid becoming pregnant. In order to confirm that you are not pregnant at predetermined intervals, you will need to take a pregnancy test.
Alcohol use is strictly prohibited during treatment with acitretin and for at least two months following the last dosage in women who are capable of becoming pregnant. Consuming alcohol might result in the conversion of acitretin in the body into a different compound, the elimination of which may take up to three years or even longer.
It is not safe for either men or women to give blood while using acitretin, and it should not be done for at least three years after the last dosage has been taken. It is possible for a pregnant woman to have a child with a birth defect if she receives donated blood that contains acitretin.
Acitretin has the potential to induce severe liver damage. If you have symptoms such as nausea, vomiting, lack of appetite, dark urine, or jaundice, you should immediately stop taking this medication and get in touch with your physician (yellowing of your skin or eyes).
Before beginning to use this medication
You should not use this medication if you have ever had an adverse reaction to any retinoid (including acitretin, isotretinoin, or tretinoin; Accutane; Claravis; Myorisan; Refissa; Renova; Retin-A; and others); or if you have a history of liver disease; or if you are pregnant or breastfeeding.
you suffer from a serious condition affecting either your liver or your kidneys;
you have a high concentration of triglycerides, which are a kind of fat, in your blood;
you are either pregnant or nursing an infant;
in addition to this, you are taking methotrexate; or
In addition, you make use of an antibiotic called tetracycline (such as demeclocycline, doxycycline, minocycline, tetracycline, and others).
Acitretin is only made available to female patients on the condition that they sign an agreement promising to practice acceptable birth control and submit to mandatory pregnancy testing while they are taking the medication as well as for at least three years following their final dosage.
If you are a woman who is taking acitretin and you have not had a hysterectomy or you have not gone completely through menopause, you are required to undergo two pregnancy tests that both come back negative before you may begin taking acitretin (when your doctor first prescribes acitretin, and again during the first 5 days of your menstrual period just before you start taking this medicine). A pregnancy test will also need to be performed on you once a month while you are taking acitretin and then once every three months for at least three years after you have finished your final dosage.
Acitretin has been linked to a number of serious birth abnormalities. Acitretin should not be used during pregnancy or if there is a possibility that a woman will get pregnant during the next three years after she has stopped taking this medication. When using acitretin and for at least three years following your last dosage, you are required to make use of two different methods of contraception that are both proven to be effective in preventing pregnancy.
One of the following kinds of birth control should be included in the initial technique of birth control:
oral contraceptives, except the "mini-pill," birth control tablets;
an intrauterine device (IUD);
injections, inserts, skin patches, or implants are all forms of birth control;
a tubal ligation; or
vasectomy performed on your male companion.
The second technique of contraception ought to involve the use of at least one of the following forms:
a cervical cap or diaphragm that is used when using spermicide;
a condom made of latex that is worn with or without the addition of a spermicide; or
a spermicide-infused vaginal sponge to prevent pregnancy.
You should begin using both methods of birth control at least one month prior to beginning treatment with acitretin. You should keep using both kinds while you are on acitretin treatment and for at least three years after you have stopped using the medication. Always use a combination of birth control methods whenever you have sexual activity.
When you are taking acitretin and for at least three years following your final dosage, you should immediately contact your doctor if you have any concerns about becoming pregnant, if you miss your period, or if you engage in sexual activity without utilizing both methods of birth control. If you have sex without taking either of the two suggested forms of birth control, you should think about using emergency contraception, sometimes known as the "morning-after pill."
If you do not have your period, you should get a pregnancy test at least 11 days from the time that you last had sexual activity without using two different types of birth control that are both equally effective.
It is imperative that you keep all of your prenatal appointments so that your doctor can determine whether or not you may continue taking acitretin.
Acitretin is known to be excreted into breast milk and has the potential to produce major adverse effects in breastfeeding infants. When you are taking this medication, you should not breastfeed your child.
Tell your doctor if you have ever been diagnosed with, treated for, or treated anybody else for any of the following conditions:
phototherapy;
illness of the kidneys or the liver;
coronary artery disease;
a high level of cholesterol or triglycerides, which are both forms of blood fat;
diabetes (in which case you would need to monitor your blood sugar levels more frequently);
a pattern of consuming huge amounts of alcohol on a regular basis;
depression; or
If you have ever taken a medication called etretinate, you should read this (Tegison, Tigason).
What is the recommended dosage for acitretin?
Always make sure to follow all of the instructions on the label of your medication. Acitretin should not be used in bigger or lower doses, or for a longer period of time than what is indicated.
Acitretin should be taken with a meal.
When you first begin taking acitretin, you may have a worsening of your psoriasis symptoms, which can take up to three months before they begin to improve. Maintain the prescribed dosage of the medicine and discuss your continued symptoms with your primary care provider if they do not improve.
If you are on acitretin, your doctor may want to check your blood more frequently. If you use this medication for an extended period of time, your doctor may recommend further exams, such as x-rays.
What should I try to steer clear of while I'm on acitretin?
Alcohol use is strictly prohibited during treatment with acitretin and for at least two months following the last dosage in women who are capable of becoming pregnant. Any amount of alcohol consumed during this time period has the potential to induce acitretin to convert to another chemical in your body, the elimination of which might take up to three years or even longer. You should check the ingredient lists of all the meals and medicines you take to ensure that they do not include any alcohol.
It is not safe for either men or women to give blood while using acitretin, and it should not be done for at least three years after the last dosage has been taken. It is possible for a pregnant woman to have a child with a birth defect if she receives donated blood that contains acitretin.
It is important to stay below the maximum amount of vitamin A that is suggested for daily consumption. Acitretin is a type of vitamin A, and most multivitamin products and nutritional supplements include vitamin A as an ingredient. It is possible to consume an unsafe amount of vitamin A if you combine the usage of certain items.
Try to limit your time spent in the sun and indoor tanning booths. Acitretin may increase your susceptibility to sunburn. Before you go outside, make sure to protect yourself by donning protective gear and using sunscreen with an SPF of at least 30.
Acitretin may cause visual problems, particularly when used at night. Be extremely cautious if you are going to be driving or engaging in any activity that needs you to have clear vision.
Effects adverse to acitretin
You should seek immediate medical attention if you have the following symptoms of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or neck.
If you develop any of the following symptoms, you should immediately stop using acitretin and notify your doctor:
alterations in mood, such as sadness, aggressiveness, thoughts or behaviors that are out of the ordinary, and suicidal ideation
Symptoms of a heart attack or a stroke include chest discomfort, dizziness, nausea, feeling short of breath, sudden numbness or weakness (particularly on one side of the body), sudden severe headache, difficulties with speech or balance, swelling or warmth in either one or both legs;
Symptoms of high blood sugar include an increase in thirst, an increase in urine, dry mouth, an odor of fruit on the breath, headache, and blurry vision.
symptoms of increased pressure inside the skull include severe headaches, ringing in the ears, dizziness, nausea, visual issues, and discomfort behind the eyes;
difficulties with the liver, including nausea, vomiting, a lack of appetite, dark urine, or jaundice (a yellowing of the skin or eyes);
issues related to your bones or muscles, such as a lack of sensation in your hands or feet, difficulty moving, or discomfort in your back, joints, muscles, or bones;
difficulties of a serious nature with your skin, such as itching, redness, discomfort, swelling, or peeling; or
Signs that you could have a problem with your blood vessels include abrupt swelling, fast weight gain, fever, muscular soreness, and a sensation of dizziness.
The following are examples of common adverse effects:
cracked lips and a parched mouth;
skin that is itchy or scaley;
weak nails, frail skin;
flaking skin on your palms and soles of your feet;
loss of hair;
discomfort caused by dry eyes and the usage of contact lenses;
dry or runny nose, nosebleeds; or
joint ache, tight muscles.
What other medications could interact with acitretin?
Talk to your primary care physician about any and all medications you are currently taking, as well as any you begin or discontinue taking, in particular:
glyburide;
phenytoin;
St. John's wort, or alternatively
replacement treatment with hormones or the use of birth control tablets (especially "minipills").
This list does not contain everything. Acitretin has the potential to interact negatively with a number of other medications, such as prescription and over-the-counter pharmaceuticals, vitamins, and herbal treatments. This drug guide does not provide a description of all potentially harmful interactions.
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