Alzheimer's And Parkinson's, Mental Disorders, Neurological DisordersNamzaric (Generic)
Generic drugs, marketed without brand names, contain the exact same active ingredients used in their brand-name counterparts, but cost significantly less. The drugs are required to meet US Food and Drug Administration (FDA) standards for safety, purity and effectiveness.
Namzaric
The antipsychotic medication known as Namzaric combines the active ingredients donepezil and memantine. The effectiveness of the brain's nerve cells is enhanced by the use of donepezil. It achieves its effect by inhibiting the decomposition of a substance known as acetylcholine. The levels of this molecule, which plays a crucial role in the processes of remembering, thinking, and reasoning, are often lower in those who suffer from dementia. The activity of substances in the brain that may contribute to the symptoms of Alzheimer's disease are diminished by the administration of memantine. Patients with moderate to severe Alzheimer's disease dementia may benefit from treatment with Namzaric.
Generic Namzaric is a combination medication that contains two active ingredients: memantine hydrochloride and donepezil hydrochloride. It is used for the treatment of moderate to severe Alzheimer's disease. Memantine is an NMDA (N-methyl-D-aspartate) receptor antagonist, while donepezil is an acetylcholinesterase inhibitor. Together, these drugs work synergistically to improve cognitive function and slow the progression of Alzheimer's disease symptoms. The combination of memantine and donepezil in a single formulation offers the convenience of reducing the pill burden for patients, which can be particularly beneficial for elderly individuals who may be managing multiple medications.
Mechanism of Action
Memantine: Memantine functions as an uncompetitive NMDA receptor antagonist. In Alzheimer's disease, excessive glutamate release leads to overactivation of NMDA receptors, causing calcium influx and subsequent neuronal damage. Memantine selectively blocks these receptors under conditions of excessive glutamate release, thereby protecting neurons from excitotoxicity while allowing normal synaptic transmission to occur.
Donepezil: Donepezil is an acetylcholinesterase inhibitor that works by increasing the levels of acetylcholine in the brain. Acetylcholine is a neurotransmitter involved in memory and learning, and its levels are typically reduced in Alzheimer's disease. By inhibiting the enzyme that breaks down acetylcholine, donepezil helps to enhance cholinergic neurotransmission, which can improve cognitive function and daily living activities.
Indications
Generic Namzaric is indicated for the treatment of moderate to severe Alzheimer's disease in patients who are already stabilized on memantine and donepezil as separate medications. It is particularly useful for patients who may benefit from the convenience of a combination therapy, reducing the number of pills they need to take daily.
Dosage and Administration
Generic Namzaric is available in various strengths, combining different doses of memantine and donepezil. The typical starting dose is based on the patient's current regimen of memantine and donepezil. For example, a common starting dose might be memantine 14 mg/donepezil 10 mg once daily. The dosage can be adjusted based on the patient's response and tolerability. It is important to follow the healthcare provider's instructions carefully and not to adjust the dose without consulting them.
Pharmacokinetics
Memantine: Memantine is well-absorbed after oral administration, with a bioavailability of approximately 100%. It has a large volume of distribution and is widely distributed throughout the body. Memantine is minimally metabolized in the liver and is primarily excreted unchanged in the urine, with an elimination half-life of about 60 to 80 hours.
Donepezil: Donepezil is also well-absorbed after oral administration, with a bioavailability of about 100%. It is extensively metabolized in the liver by the cytochrome P450 system, primarily CYP3A4 and CYP2D6 enzymes. The metabolites are then excreted in the urine, with an elimination half-life of approximately 70 hours.
Clinical Efficacy
Clinical studies have demonstrated the efficacy of the combination of memantine and donepezil in improving cognitive function, global clinical status, and activities of daily living in patients with moderate to severe Alzheimer's disease. The combination therapy has been shown to provide greater benefits than either drug alone, particularly in slowing the progression of symptoms and improving quality of life for patients and caregivers.
Safety and Tolerability
Generic Namzaric is generally well-tolerated, but like all medications, it can cause side effects. The most common side effects include:
These side effects are usually mild to moderate and tend to diminish with continued use. Serious adverse events are rare but can include bradycardia, syncope, seizures, and gastrointestinal bleeding. Patients should be monitored closely, especially when starting treatment or adjusting the dose.
Drug Interactions
Given that Generic Namzaric contains two active ingredients, it is important to consider potential drug interactions for both memantine and donepezil.
Memantine:
NMDA Receptor Antagonists: Concurrent use with other NMDA receptor antagonists (e.g., amantadine, ketamine) may increase the risk of adverse effects.
Urinary Alkalinizers: Drugs that alkalinize the urine (e.g., carbonic anhydrase inhibitors) may reduce the excretion of memantine, leading to increased plasma levels.
Donepezil:
Cholinergic Agents: Concurrent use with other cholinergic agents may increase the risk of cholinergic side effects.
CYP3A4 and CYP2D6 Inhibitors: Drugs that inhibit these enzymes (
tablet forms of donepezil with memantine
What kind of medication is this?
The effectiveness of the brain's nerve cells is enhanced by the use of DONEZEPIL. It achieves its effect by inhibiting the decomposition of a substance known as acetylcholine. The levels of this molecule, which plays a crucial role in the processes of remembering, thinking, and reasoning, are often lower in those who suffer from dementia. The activity of substances in the brain that may contribute to the symptoms of Alzheimer's disease are inhibited by the medication known as MEMANTINE.
Tablets containing donezepil and memantine are administered to patients suffering from mild to severe Alzheimer's disease dementia.
Tablets containing donezepil and memantine are not a treatment that can reverse the effects of Alzheimer's disease. Even in patients who are taking donepezil, the symptoms of this illness will worsen over time.
Before I start using this medication, what should I discuss with my health care providers?
If you have an allergy to donepezil or memantine, you should avoid using any medications that include these ingredients.
Tell your doctor if you have any of the following conditions or have had any in the past: asthma or another breathing disorder; heart disease or heart rhythm disorder; a history of seizures; stomach ulcer or a history of stomach or intestinal bleeding; bladder obstruction or other urination problems; liver disease; or kidney disease. This will help your doctor determine whether or not the medication is safe for you to take.
It is unknown at this time if donezepil or memantine will cause damage to an unborn child. Inform your physician if you are pregnant or if you want to become pregnant in the near future.
It is unknown whether donepezil and memantine transfer into breast milk or whether it might cause damage to a baby who is being breastfed. If you are breastfeeding a child, you should let your doctor know about it.
What is the correct way to take this medication?
Always follow your physician's instructions to the letter when taking medication. Always make sure to follow all of the instructions on the label of your medication. This drug should not be used in bigger or lesser dosages, nor should it be taken for a longer period of time than is indicated.
Unless your doctor instructs you otherwise, take your medication in the evening before going to bed.
You can take your medication with or without meals, whichever you choose.
In the event that you require dental work or surgery, it is imperative that you inform the surgeon in advance that you are currently taking medication. It is possible that you will need to refrain from using the medication temporarily.
You shouldn't just stop taking your medication all of a sudden. It's possible that if you stop suddenly, your condition will get worse.
Keep medications away from moisture, heat, and light, and store them at room temperature.
What other substances could react with this medication?
Other medications, including as prescription and over-the-counter pharmaceuticals, vitamins, and herbal remedies, might potentially have an adverse reaction when used with donepezil and memantine. Inform all of your health care providers about any and all medications you are currently taking, as well as any and all medications you begin or stop taking.
What potential negative reactions may I have to this medication?
If you develop symptoms of an allergic response to Namzaric, such as hives, difficulty breathing, or swelling of the face, lips, tongue, or neck, you should seek immediate medical attention.
If you experience any of the following side effects while taking this medication: severe or ongoing vomiting; a lightheaded feeling, as if you might pass out; slow heartbeats; seizure (convulsions); painful or difficult urination; new or worsening breathing problems; or signs of stomach bleeding, such as severe heartburn or stomach pain, bloody or tarry stools, coughing up blood, or vomit that looks like coffee grounds. Immediately stop using this medication and call your doctor if
Typical adverse reactions to Namzaric may include feeling sick, throwing up, having diarrhea, losing your appetite, having a headache, feeling dizzy, or easily bruising.
This list of potential adverse effects is not exhaustive; additional symptoms may also surface.
What side effects should I be on the lookout for when using this medication?
Always be sure to follow your doctor's recommendations regarding any dietary, beverage, or exercise limitations.
Testimonials
What’s great about this site is they have such a wide
selection of products. I wasn’t happy with my current ED product was using, so I was able to
try out a different kind and see if it was a better fit for my needs. Which it was!
– John, Wellington
I have been buying brand meds name for years and it never
crossed my mind how much cheaper the generic versions were. When I started browsing the
items I couldn’t believe the price difference! This is my go to shop right now.
– Eric, London
I wasn’t quite sure about buying my medication online as I
always bought it in store. I spoke to one of their support reps and they were really nice
and helped to explain how it works and made me feel much more comfortable with my order!
– Jenna, Leeds
has all the best generic items at crazy good prices. I order here every month.
– Pete, Birmingham
I got my package in just under a week with no problems at all!
Highly recommended.
– Jerry, Quebec
It was my first time ordering at
and it definitely won’t be my last! They had all the items I needed in one place and the
prices are the best I could find online.
– Phil, Ontario
I used to buy my meds online but I had to pay a good amount
for shipping. When I found this site I was thrilled to see they offer free discreet
shipping. I am saving significantly more money.
– Arthur, Vancouver
You cannot compare the prices found at
to anywhere else online. These are the best prices by far!
– Barbara, Auckland
What’s great about this site is they have such a wide
selection of products. I wasn’t happy with my current ED product was using, so I was able to
try out a different kind and see if it was a better fit for my needs. Which it was!
– John, Wellington
I have been buying brand meds name for years and it never
crossed my mind how much cheaper the generic versions were. When I started browsing the
items I couldn’t believe the price difference! This is my go to shop right now.
– Eric, London
I wasn’t quite sure about buying my medication online as I
always bought it in store. I spoke to one of their support reps and they were really nice
and helped to explain how it works and made me feel much more comfortable with my order!
– Jenna, Leeds
has all the best generic items at crazy good prices. I order here every month.
– Pete, Birmingham
I got my package in just under a week with no problems at all!
Highly recommended.
– Jerry, Quebec
It was my first time ordering at
and it definitely won’t be my last! They had all the items I needed in one place and the
prices are the best I could find online.
– Phil, Ontario
I used to buy my meds online but I had to pay a good amount
for shipping. When I found this site I was thrilled to see they offer free discreet
shipping. I am saving significantly more money.
– Arthur, Vancouver
You cannot compare the prices found at
to anywhere else online. These are the best prices by far!
– Barbara, Auckland
