HIVTivicay (Generic)
Generic drugs, marketed without brand names, contain the exact same active ingredients used in their brand-name counterparts, but cost significantly less. The drugs are required to meet US Food and Drug Administration (FDA) standards for safety, purity and effectiveness.
Tivicay
Dolutegravir is an antiviral treatment that is used in conjunction with other medications to treat HIV, which is the virus that can lead to acquired immunodeficiency syndrome (also known as AIDS). The antiretroviral drug dolutegravir is not a treatment for HIV or AIDS. Dolutegravir can be administered to both adults and infants as early as 4 weeks old as long as the kid weighs at least 6 pounds (3 kilograms).
Generic Tivicay, known generically as dolutegravir, is an antiretroviral medication used primarily in the treatment of HIV (Human Immunodeficiency Virus) infection. It belongs to the class of drugs known as integrase strand transfer inhibitors (INSTIs), which work by blocking the integrase enzyme that HIV needs to multiply. This action helps to reduce the amount of HIV in the body, thereby improving the immune system and reducing the risk of developing AIDS (Acquired Immunodeficiency Syndrome) and other HIV-related complications.
Development and Approval
Dolutegravir was developed by ViiV Healthcare, a global specialist HIV company established by GlaxoSmithKline (GSK) and Pfizer. It received approval from the U.S. Food and Drug Administration (FDA) in August 2013 under the brand name Tivicay. Since then, it has become a cornerstone in HIV treatment regimens due to its efficacy, safety profile, and high barrier to resistance.
The introduction of generic versions of dolutegravir has been a significant development in the global fight against HIV, particularly in low- and middle-income countries (LMICs). Generic Tivicay has made the drug more accessible and affordable, enabling broader treatment coverage and improving the quality of life for millions of people living with HIV.
Mechanism of Action
Dolutegravir works by inhibiting the integrase enzyme, which is essential for the replication of HIV. Integrase is responsible for inserting the viral DNA into the DNA of the host cell, a critical step in the HIV life cycle. By blocking this enzyme, dolutegravir prevents the virus from integrating into the host genome, thereby halting its replication and reducing the viral load in the body.
Indications and Usage
Generic Tivicay is indicated for the treatment of HIV-1 infection in adults and pediatric patients weighing at least 30 kg. It is used in combination with other antiretroviral agents as part of a complete treatment regimen. The drug is suitable for both treatment-naïve patients (those who have never taken antiretroviral therapy before) and treatment-experienced patients (those who have previously received other antiretroviral regimens).
Dosage and Administration
The standard dosage of generic Tivicay for most patients is 50 mg once daily. However, the dosage may vary depending on the patient's medical history, concomitant medications, and specific treatment needs. For instance, patients taking certain medications that interact with dolutegravir may require a different dosing regimen.
Generic Tivicay is available in tablet form and should be taken orally with or without food. It is crucial for patients to adhere to their prescribed dosage and follow their healthcare provider's instructions to achieve the best possible outcomes.
Efficacy and Clinical Trials
The efficacy of dolutegravir has been demonstrated in numerous clinical trials. In the SINGLE trial, dolutegravir-based regimens were shown to be superior to efavirenz-based regimens in terms of viral suppression and tolerability. Similarly, the FLAMINGO trial demonstrated that dolutegravir was more effective than darunavir, another commonly used antiretroviral drug.
These trials, along with others, have established dolutegravir as a highly effective option for HIV treatment, with a rapid reduction in viral load and a high rate of virological suppression. The drug's high barrier to resistance is another significant advantage, making it a reliable choice for long-term management of HIV.
Safety and Side Effects
Generic Tivicay is generally well-tolerated, but like all medications, it can cause side effects. Common side effects include headache, nausea, diarrhea, and insomnia. Most of these side effects are mild to moderate in severity and tend to resolve on their own as the body adjusts to the medication.
Serious side effects are rare but can occur. These include hypersensitivity reactions, liver problems, and changes in immune response (immune reconstitution inflammatory syndrome, or IRIS). Patients should seek medical attention if they experience symptoms such as rash, fever, fatigue, yellowing of the skin or eyes, or severe abdominal pain.
Drug Interactions
Dolutegravir can interact with other medications, potentially affecting its efficacy or increasing the risk of side effects. Notable drug interactions include:
Metformin: Dolutegravir can increase the concentration of metformin, a medication used to treat diabetes. Dose adjustments may be necessary.
Antacids and Supplements: Calcium, magnesium, and iron-containing products can reduce the absorption of dolutegravir. It is recommended to take these products at least 2 hours before or 6 hours after taking dolutegravir.
Rifampin: This tuberculosis medication can reduce dolutegravir levels. An increased dose of dolutegravir may be required when co-administered with rifampin.
Patients should inform their healthcare provider of all medications, supplements, and herbal products they are taking to avoid potential interactions.
Special Populations
Pregnancy: Dolutegravir is generally considered safe for use during pregnancy, but it is essential to consult with a healthcare provider to weigh the benefits and risks. Recent studies have shown that dolutegravir-based regimens are effective and well-tolerated in pregnant women.
Pediatrics: Generic Tivicay is approved for use in pediatric patients weighing at least 30 kg. The dosage is adjusted based on the child's weight and other factors.
Elderly: Older adults may be more susceptible to the side effects of dolutegravir, and dose adjustments may be necessary based on renal function and overall health.
Cost and Accessibility
The availability of generic Tivicay has significantly reduced the cost of HIV treatment, making it more accessible to patients worldwide. In many LMICs, generic dolutegravir is now the preferred first-line treatment for HIV due to its affordability and effectiveness. This has been a game-changer in the global effort to combat the HIV epidemic, particularly in regions where the burden of the disease is highest.
Conclusion
Generic Tivicay (dolutegravir) represents a major advancement in HIV treatment. Its high efficacy, favorable safety profile, and high barrier to resistance make it a cornerstone of modern antiretroviral therapy. The introduction of generic versions has further enhanced its accessibility, enabling more people to benefit from this life-saving medication.
As with any medication, it is crucial for patients to work closely with their healthcare providers to ensure proper use, monitor for side effects, and achieve the best possible outcomes. With continued efforts to improve access and adherence, generic Tivicay holds the promise of transforming the lives of millions of people living with HIV and bringing us closer to the goal of ending the HIV epidemic.
Tivicay
What exactly is the Tivicay?
Tivicay is an antiviral medication that stops human immunodeficiency virus (HIV) from growing in your body so that you can live a normal life.
Tivicay is an antiviral medicine that, when combined with other antiviral drugs, is used to treat HIV, which is the virus that can lead to acquired immunodeficiency syndrome (AIDS) (AIDS).
Tivicay is not a treatment that can reverse HIV or AIDS.
Tablets of Tivicay are intended for usage in both adults and children who are able to chew pills.
Tablets for oral suspension of Tivicay PD are intended for use in newborns and children who have reached at least four weeks of age and who weigh at least 6 pounds (3 kilograms).
Warnings
If you are also on dofetilide, you should not use the medication Tivicay (Tikosyn).
Using Tivicay during the first three months of a woman's pregnancy may increase her risk of having a child with a birth defect. When you are on dolutegravir, it is imperative that you practice reliable birth control in order to avoid becoming pregnant.
Before beginning to use this medication
Tivicay is not something you should take if you have ever had an allergic reaction to dolutegravir or if you are also on dofetilide (Tikosyn).
Please let your doctor know if you have ever been diagnosed with:
� diseases of the liver, most notably hepatitis B or hepatitis C.
Before beginning treatment with Tivicay, your doctor will want to make sure that you have a negative pregnancy test.
If you use Tivicay around the time of conception or within the first 12 weeks of your pregnancy, there is a risk that the medication will damage your unborn child. Be sure you're not pregnant by using an effective method of birth control, and consult your physician if you do become pregnant.
If the virus is not managed properly during pregnancy, it is possible for it to be passed on to the baby. If you are pregnant, there is a possibility that your name may be added to a register that monitors the effects of antiviral medication on the developing baby. Make sure you take all of your HIV medicine as directed.
It is not recommended that mothers who have HIV or AIDS breastfeed their children. It is possible for your infant to get HIV from you through breast milk even if they do not have the virus at birth.
What dosage of Tivicay should I take?
Tivicay should be taken in the manner directed by your physician. Read all of the medication guides or instruction papers that come with your medicine, and make sure to follow all of the guidelines that are included on the prescription label.
You can take Tivicay with or without food. Both methods are OK.
Tivicay PD dispersible tablets should not be crushed or chewed and should be swallowed whole. You can take the pill as is, or you can dissolve it in a little bit of water beforehand. Give the pill some time to break up (it will not dissolve completely). Mix the ingredients together, then give them to the child immediately away. The quantity of water that must be consumed is going to be determined by the number of pills that are required for your child's dosage. Always make sure to follow the directions that come with your medication.
When administering dolutegravir to children, the dosage is determined by their weight. The appropriate dosage for your child may need to be adjusted if the youngster has a weight increase or loss.
If your kid is going to be using Tivicay PD tablets for oral suspension, be sure to read the directions for use that come with the medication for specifics on how to prepare a dosage.
Tivicay PD should not be chewed, chopped, or crushed before swallowing, but can be taken in its entirety or mixed with water for drinking.
Tivicay tablets and Tivicay PD tablets for oral suspension are not interchangeable since they are not the same thing and cannot be used in place of one another. To avoid accidentally administering the incorrect medication to yourself or your kid, check to see that the prescription for Tivicay is filled with the appropriate formulation each time it is filled.
It is possible that you will need to get your blood checked often while using Tivicay.
If you have ever been diagnosed with hepatitis B, using dolutegravir may cause the virus to become active or for the condition to become more severe. While you are taking this medication, and perhaps for several months after you stop using it, you may require periodic liver function tests.
Take all of your HIV medicine exactly as prescribed, and make sure you read all of the instruction manuals that come with it. Do not adjust either your dose or your dosing regimen without first consulting your physician. Every individual living with HIV should continue to receive treatment from a medical professional.
Keep at room temperature and away from heat and moisture when storing. Maintain the pills in their original packaging and store them with any moisture-absorbent preservatives that come in packets or containers.
What can I expect if I forget to take a dose?
You should take the medication as soon as it is convenient for you to do so, but you should omit the missed dose if it is almost time for your next scheduled dosage. It is not recommended to take two dosages at once.
It is important that you have the prescription for your medicine renewed before you run out completely.
What happens if I overdose?
Immediately seek out the assistance of a qualified medical professional or dial the Poison Help line at 1-800-222-1222.
What should be avoided
The consumption of this medication will not stop the contagiousness of your illness. Do not engage in unprotected sexual activity, nor should you share utensils such as razors or toothbrushes. Have a conversation with your healthcare provider about the best and safest strategies to stop the spread of HIV via sexual activity. It is never safe, even for a healthy individual, to share needles that have been used for drugs or medicine.
adverse reactions to Tivicay
If you experience symptoms of an allergic reaction to Tivicay, including but not limited to the following: fever, a general feeling of illness, difficulty breathing, tiredness; joint or muscle pain; blisters or mouth sores; redness or swelling in your eyes; blistering or peeling skin; swelling of the face, lips, tongue, or throat; stop taking this medicine and get emergency medical help if you experience any of these symptoms.
You should see your physician as soon as possible if you have:
� the initial manifestation of any skin rash, regardless of how minor it is; or
� Symptoms of liver disease include nausea, vomiting, lack of appetite, upper stomach discomfort, jaundice, dark urine, and feces that have a clay-like consistency (yellowing of the skin or eyes).
Since dolutegravir has an influence on your immune system, you may have some adverse effects as a result (even weeks or months after you've stopped taking this prescription). Inform your primary care provider if you have:
� symptoms that indicate the presence of a new infection, including fever, night sweats, swollen glands, cold sores, cough, wheezing, diarrhea, and loss of weight;
� difficulty eating or speaking, issues with balance or eye movement, feeling weak or prickly, or any combination of these symptoms
� enlargement in your neck or throat (a sign of an enlarged thyroid), abnormalities in your menstrual cycle, and impotence.
Common side effects of Tivicay may include the following:
� pain in the brain;
� feelings of exhaustion; or
� sleep troubles (insomnia).
Which additional substances will have an effect on Tivicay?
When used at the same time as other medications, dolutegravir's effectiveness may be significantly reduced. If you are going to take any of the medications listed below, you should take your Tivicay dosage either two hours before or six hours after you take the other medication.
� antacids, laxatives, or the ulcer medication sucralfate (Carafate) that include calcium, magnesium, or aluminum (such as Amphojel, Di-Gel Maalox, Milk of Magnesia, Mylanta, Pepcid Complete, Rolaids, Rulox, Tums, and others);
� medications that are buffered; or
� dietary supplements of vitamins or minerals that are rich in calcium or iron (but if you take Tivicay with food, you can take these supplements at the same time).
Talk to your primary care provider about all of your other medications, in particular:
� a treatment for diabetes that is taken orally and contains metformin;
� medicine for TB that contains rifampin;
� the herb known as St. John's wort;
� other HIV or AIDS drugs - efavirenz, etravirine, fosamprenavir/ritonavir, nevirapine, tipranavir/ritonavir; or
� seizure medicine - carbamazepine, oxcarbazepine, phenobarbital, phenytoin.
This list does not contain everything. Dolutegravir may interact with a variety of other medications, including those obtained with a prescription, those obtained without a prescription, vitamins, and herbal items. This page does not provide a complete listing of all possible medication interactions.
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selection of products. I wasn’t happy with my current ED product was using, so I was able to
try out a different kind and see if it was a better fit for my needs. Which it was!
– John, Wellington
I have been buying brand meds name for years and it never
crossed my mind how much cheaper the generic versions were. When I started browsing the
items I couldn’t believe the price difference! This is my go to shop right now.
– Eric, London
I wasn’t quite sure about buying my medication online as I
always bought it in store. I spoke to one of their support reps and they were really nice
and helped to explain how it works and made me feel much more comfortable with my order!
– Jenna, Leeds
has all the best generic items at crazy good prices. I order here every month.
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I got my package in just under a week with no problems at all!
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It was my first time ordering at
and it definitely won’t be my last! They had all the items I needed in one place and the
prices are the best I could find online.
– Phil, Ontario
I used to buy my meds online but I had to pay a good amount
for shipping. When I found this site I was thrilled to see they offer free discreet
shipping. I am saving significantly more money.
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to anywhere else online. These are the best prices by far!
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